Exosomal miR-3682-3p Suppresses Angiogenesis by Targeting ANGPT1 via the RAS-MEK1/2-ERK1/2 Pathway in Hepatocellular Carcinoma

Exosomal miR-3682-3p Suppresses Angiogenesis by Targeting ANGPT1 via the RAS-MEK1/2-ERK1/2 Pathway in Hepatocellular Carcinoma

BackgroundAngiogenesis is a crucial process in tumorigenesis and development. The role of exosomes derived from hepatocellular carcinoma (HCC) cells in angiogenesis has not been clearly elucidated.Methods and ResultsExosomes were isolated from HCC cell lines (HCCLM3, MHCC97L, and PLC/RFP/5) by ultra...

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Bibliographic Details
Main Authors: Shuang-Shuang Dong, Dan-Dan Dong, Zhang-Fu Yang, Gui-Qi Zhu, Dong-Mei Gao, Jie Chen, Yan Zhao, Bin-Bin Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
HCC
exosomes
angiogenesis
miR-3682-3p
ANGPT1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.633358/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.633358/full

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