Diabetes mellitus and drug abuse during pregnancy and the risk for orofacial clefts and related abnormalities
Abstract Objective: to assessed the prevalence of diabetes mellitus (DM) and drug abuse in mothers of children with orofacial clefts (OFC). Methods: 325 women who had children (0-3y) with clefts were interviewed. Data regarding type of diabetes, use of legal/illegal drugs during pregnancy, waist...
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doaj-5e4090d8efc34780b85b86bc665ac4fc2020-11-24T22:44:48ZengUniversidade de São PauloRevista Latino-Americana de Enfermagem1518-834524010.1590/1518-8345.0815.2701S0104-11692016000100354Diabetes mellitus and drug abuse during pregnancy and the risk for orofacial clefts and related abnormalitiesIvy Kiemle Trindade-SuedamLília Maria von KostrischLuiz André Freire PimentaCarlos Antônio NegratoSolange Braga FranzolinAlceu Sergio Trindade JuniorAbstract Objective: to assessed the prevalence of diabetes mellitus (DM) and drug abuse in mothers of children with orofacial clefts (OFC). Methods: 325 women who had children (0-3y) with clefts were interviewed. Data regarding type of diabetes, use of legal/illegal drugs during pregnancy, waist girth and fasting blood sugar at the first prenatal consult were collected. Results: twenty seven percent of the women had DM, out of these, 89% had gestational DM, 5,5% type 1 DM and 5,5% type 2 DM. The prevalence of DM in mothers of children with OFC was 27%, it is significantly higher than the average Brazilian population which is 7.6% (p<0.01) (OR=4.5, 95%CI=3.5-5.8). Regarding drug abuse during pregnancy, 32% of the mothers used drugs and a significant positive correlation was observed between drug abuse and the occurrence of clefts and other craniofacial anomalies (p=0.028) (OR=2.87; 95%CI=1.1-7.4). Conclusions: DM and drug abuse during pregnancy increases the risk for OFC and related anomalies and early diagnosis of DM and prevention of drug abuse, especially in pregnant women, should be emphasized.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-11692016000100354&lng=en&tlng=enFisura del PaladarDiabetes Mellitus, EpidemiologíaTrastornos Relacionados con Sustancias |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ivy Kiemle Trindade-Suedam Lília Maria von Kostrisch Luiz André Freire Pimenta Carlos Antônio Negrato Solange Braga Franzolin Alceu Sergio Trindade Junior |
spellingShingle |
Ivy Kiemle Trindade-Suedam Lília Maria von Kostrisch Luiz André Freire Pimenta Carlos Antônio Negrato Solange Braga Franzolin Alceu Sergio Trindade Junior Diabetes mellitus and drug abuse during pregnancy and the risk for orofacial clefts and related abnormalities Revista Latino-Americana de Enfermagem Fisura del Paladar Diabetes Mellitus, Epidemiología Trastornos Relacionados con Sustancias |
author_facet |
Ivy Kiemle Trindade-Suedam Lília Maria von Kostrisch Luiz André Freire Pimenta Carlos Antônio Negrato Solange Braga Franzolin Alceu Sergio Trindade Junior |
author_sort |
Ivy Kiemle Trindade-Suedam |
title |
Diabetes mellitus and drug abuse during pregnancy and the risk for orofacial clefts and related abnormalities |
title_short |
Diabetes mellitus and drug abuse during pregnancy and the risk for orofacial clefts and related abnormalities |
title_full |
Diabetes mellitus and drug abuse during pregnancy and the risk for orofacial clefts and related abnormalities |
title_fullStr |
Diabetes mellitus and drug abuse during pregnancy and the risk for orofacial clefts and related abnormalities |
title_full_unstemmed |
Diabetes mellitus and drug abuse during pregnancy and the risk for orofacial clefts and related abnormalities |
title_sort |
diabetes mellitus and drug abuse during pregnancy and the risk for orofacial clefts and related abnormalities |
publisher |
Universidade de São Paulo |
series |
Revista Latino-Americana de Enfermagem |
issn |
1518-8345 |
description |
Abstract Objective: to assessed the prevalence of diabetes mellitus (DM) and drug abuse in mothers of children with orofacial clefts (OFC). Methods: 325 women who had children (0-3y) with clefts were interviewed. Data regarding type of diabetes, use of legal/illegal drugs during pregnancy, waist girth and fasting blood sugar at the first prenatal consult were collected. Results: twenty seven percent of the women had DM, out of these, 89% had gestational DM, 5,5% type 1 DM and 5,5% type 2 DM. The prevalence of DM in mothers of children with OFC was 27%, it is significantly higher than the average Brazilian population which is 7.6% (p<0.01) (OR=4.5, 95%CI=3.5-5.8). Regarding drug abuse during pregnancy, 32% of the mothers used drugs and a significant positive correlation was observed between drug abuse and the occurrence of clefts and other craniofacial anomalies (p=0.028) (OR=2.87; 95%CI=1.1-7.4). Conclusions: DM and drug abuse during pregnancy increases the risk for OFC and related anomalies and early diagnosis of DM and prevention of drug abuse, especially in pregnant women, should be emphasized. |
topic |
Fisura del Paladar Diabetes Mellitus, Epidemiología Trastornos Relacionados con Sustancias |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-11692016000100354&lng=en&tlng=en |
work_keys_str_mv |
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