Melatonin Suppresses Microglial Necroptosis by Regulating Deubiquitinating Enzyme A20 After Intracerebral Hemorrhage

Melatonin Suppresses Microglial Necroptosis by Regulating Deubiquitinating Enzyme A20 After Intracerebral Hemorrhage

Cell death is deeply involved in pathophysiology of brain injury after intracerebral hemorrhage (ICH). Necroptosis, one of the recently discovered forms of cell death, plays an important role in various diseases, including ICH. Previous studies have suggested that a considerable number of neurons un...

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Bibliographic Details
Main Authors: Jianan Lu, Zeyu Sun, Yuanjian Fang, Jingwei Zheng, Shenbin Xu, Weilin Xu, Ligen Shi, Shuhao Mei, Haijian Wu, Feng Liang, Jianmin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
intracerebral hemorrhage (ICH)
necroptosis
microglia
melatonin
A20
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01360/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01360/full

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