Exposure of Intestinal Epithelial Cells to Short- and Long-Chain Fructo-Oligosaccharides and CpG Oligodeoxynucleotides Enhances Peanut-Specific T Helper 1 Polarization

Exposure of Intestinal Epithelial Cells to Short- and Long-Chain Fructo-Oligosaccharides and CpG Oligodeoxynucleotides Enhances Peanut-Specific T Helper 1 Polarization

BackgroundNon-digestible oligosaccharides promote colonization of beneficial gut bacteria and have direct immunomodulatory effects. Apical exposure of intestinal epithelial cells (IECs) to short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides (scGOS/lcFOS) in a transwell co-cul...

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Bibliographic Details
Main Authors: Simone M. Hayen, Henny G. Otten, Saskia A. Overbeek, André C. Knulst, Johan Garssen, Linette E. M. Willemsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
allergen-specific
immunomodulation
non-digestible oligosaccharides
co-culture
epithelial cells
T cell polarization
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00923/full

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