Regulation of the CaV3.2 calcium channels in health and disease Regulácia CaV3.2 vápnikových kanálov v zdraví a chorobe

Regulation of the CaV3.2 calcium channels in health and disease Regulácia CaV3.2 vápnikových kanálov v zdraví a chorobe

Family of T-type or low-voltage activated calcium channels consists of three members: CaV3.1, CaV3.2, and CaV3.3. CaV3.2 channel has almost identical biophysical properties as the CaV3.1 channel, but is distinguished by a specific tissue expression profile and a prominent role in several pathologies...

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Main Author: Lacinová Ľ.
Format: Article
Language:English
Published: Sciendo 2017-11-01
Series:European Pharmaceutical Journal
Subjects:
t-type calcium channel - cav3.2 - regulation - trafficking - glycosylation
Online Access:https://doi.org/10.1515/afpuc-2017-0019
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spelling doaj-5eccd05a93164ff0b76eb1ac00fde26c2021-09-06T19:39:44ZengSciendoEuropean Pharmaceutical Journal2453-67252017-11-01642152110.1515/afpuc-2017-0019Regulation of the CaV3.2 calcium channels in health and disease Regulácia CaV3.2 vápnikových kanálov v zdraví a chorobeLacinová Ľ.0Slovenská akadémia vied, Biomedicínske centrum SAV, Bratislava, SlovakiaFamily of T-type or low-voltage activated calcium channels consists of three members: CaV3.1, CaV3.2, and CaV3.3. CaV3.2 channel has almost identical biophysical properties as the CaV3.1 channel, but is distinguished by a specific tissue expression profile and a prominent role in several pathologies, including neuropathic pain, epilepsy, and dysregulation of cardiac rhythm. Further, it may be involved in phenotype of autism spectrum disorders, and amyotrophic lateral sclerosis. It represents a promising target for future pharmacotherapies.https://doi.org/10.1515/afpuc-2017-0019t-type calcium channel - cav3.2 - regulation - trafficking - glycosylation
collection DOAJ
language English
format Article
sources DOAJ
author Lacinová Ľ.
spellingShingle Lacinová Ľ.
Regulation of the CaV3.2 calcium channels in health and disease Regulácia CaV3.2 vápnikových kanálov v zdraví a chorobe
European Pharmaceutical Journal
t-type calcium channel - cav3.2 - regulation - trafficking - glycosylation
author_facet Lacinová Ľ.
author_sort Lacinová Ľ.
title Regulation of the CaV3.2 calcium channels in health and disease Regulácia CaV3.2 vápnikových kanálov v zdraví a chorobe
title_short Regulation of the CaV3.2 calcium channels in health and disease Regulácia CaV3.2 vápnikových kanálov v zdraví a chorobe
title_full Regulation of the CaV3.2 calcium channels in health and disease Regulácia CaV3.2 vápnikových kanálov v zdraví a chorobe
title_fullStr Regulation of the CaV3.2 calcium channels in health and disease Regulácia CaV3.2 vápnikových kanálov v zdraví a chorobe
title_full_unstemmed Regulation of the CaV3.2 calcium channels in health and disease Regulácia CaV3.2 vápnikových kanálov v zdraví a chorobe
title_sort regulation of the cav3.2 calcium channels in health and disease regulácia cav3.2 vápnikových kanálov v zdraví a chorobe
publisher Sciendo
series European Pharmaceutical Journal
issn 2453-6725
publishDate 2017-11-01
description Family of T-type or low-voltage activated calcium channels consists of three members: CaV3.1, CaV3.2, and CaV3.3. CaV3.2 channel has almost identical biophysical properties as the CaV3.1 channel, but is distinguished by a specific tissue expression profile and a prominent role in several pathologies, including neuropathic pain, epilepsy, and dysregulation of cardiac rhythm. Further, it may be involved in phenotype of autism spectrum disorders, and amyotrophic lateral sclerosis. It represents a promising target for future pharmacotherapies.
topic t-type calcium channel - cav3.2 - regulation - trafficking - glycosylation
url https://doi.org/10.1515/afpuc-2017-0019
work_keys_str_mv AT lacinoval regulationofthecav32calciumchannelsinhealthanddiseaseregulaciacav32vapnikovychkanalovvzdraviachorobe
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