In vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta

Akira Kobayashi, Tomomi Higashide, Hideaki Yokogawa, Natsuko Yamazaki, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Objective: To report the in vivo laser confocal microscopy findings of a cornea with osteo...

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Main Authors: Kobayashi A, Higashide T, Yokogawa H, Yamazaki N, Masaki T, Sugiyama K
Format: Article
Language:English
Published: Dove Medical Press 2014-02-01
Series:Clinical Ophthalmology
Online Access:http://www.dovepress.com/in-vivo-laser-confocal-microscopy-findings-of-a-cornea-with-osteogenes-a15911
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spelling doaj-5f285e4932a243448f7e9e7889f749ff2020-11-25T00:24:48ZengDove Medical PressClinical Ophthalmology1177-54832014-02-012014default42943315911In vivo laser confocal microscopy findings of a cornea with osteogenesis imperfectaKobayashi AHigashide TYokogawa HYamazaki NMasaki TSugiyama K Akira Kobayashi, Tomomi Higashide, Hideaki Yokogawa, Natsuko Yamazaki, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Objective: To report the in vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta (OI) with special attention to the abnormality of Bowman's layer and sub-Bowman's fibrous structures (K-structures). Patients and methods: Two patients (67-year-old male and his 26-year-old son) with OI type I were included in this study. Slit lamp biomicroscopic and in vivo laser confocal microscopic examinations were performed for both patients. Central corneal thickness and central endothelial cell density were also measured. Results: Although the corneas looked clear with normal endothelial density for both eyes in both patients, they were quite thin (386 µm oculus dexter (OD) (the right eye) and 384 µm oculus sinister (OS) (the left eye) in the father and 430 µm OD and 425 µm OS in the son). In both patients, slit lamp biomicroscopic and in vivo laser confocal microscopic examination showed similar results. Anterior corneal mosaics produced by rubbing the eyelid under fluorescein were completely absent in both eyes. In vivo laser confocal microscopy revealed an absent or atrophic Bowman's layer; a trace of a presumed Bowman's layer and/or basement membrane was barely visible with high intensity. Additionally, K-structures were completely absent in both eyes. Conclusion: The absence of K-structures and fluorescein anterior corneal mosaics strongly suggested an abnormality of Bowman's layer in these OI patients. Keywords: osteogenesis imperfecta, K-structure, confocal microscopy, Bowman's layerhttp://www.dovepress.com/in-vivo-laser-confocal-microscopy-findings-of-a-cornea-with-osteogenes-a15911
collection DOAJ
language English
format Article
sources DOAJ
author Kobayashi A
Higashide T
Yokogawa H
Yamazaki N
Masaki T
Sugiyama K
spellingShingle Kobayashi A
Higashide T
Yokogawa H
Yamazaki N
Masaki T
Sugiyama K
In vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta
Clinical Ophthalmology
author_facet Kobayashi A
Higashide T
Yokogawa H
Yamazaki N
Masaki T
Sugiyama K
author_sort Kobayashi A
title In vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta
title_short In vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta
title_full In vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta
title_fullStr In vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta
title_full_unstemmed In vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta
title_sort in vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta
publisher Dove Medical Press
series Clinical Ophthalmology
issn 1177-5483
publishDate 2014-02-01
description Akira Kobayashi, Tomomi Higashide, Hideaki Yokogawa, Natsuko Yamazaki, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Objective: To report the in vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta (OI) with special attention to the abnormality of Bowman's layer and sub-Bowman's fibrous structures (K-structures). Patients and methods: Two patients (67-year-old male and his 26-year-old son) with OI type I were included in this study. Slit lamp biomicroscopic and in vivo laser confocal microscopic examinations were performed for both patients. Central corneal thickness and central endothelial cell density were also measured. Results: Although the corneas looked clear with normal endothelial density for both eyes in both patients, they were quite thin (386 µm oculus dexter (OD) (the right eye) and 384 µm oculus sinister (OS) (the left eye) in the father and 430 µm OD and 425 µm OS in the son). In both patients, slit lamp biomicroscopic and in vivo laser confocal microscopic examination showed similar results. Anterior corneal mosaics produced by rubbing the eyelid under fluorescein were completely absent in both eyes. In vivo laser confocal microscopy revealed an absent or atrophic Bowman's layer; a trace of a presumed Bowman's layer and/or basement membrane was barely visible with high intensity. Additionally, K-structures were completely absent in both eyes. Conclusion: The absence of K-structures and fluorescein anterior corneal mosaics strongly suggested an abnormality of Bowman's layer in these OI patients. Keywords: osteogenesis imperfecta, K-structure, confocal microscopy, Bowman's layer
url http://www.dovepress.com/in-vivo-laser-confocal-microscopy-findings-of-a-cornea-with-osteogenes-a15911
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