Critical role of methylglyoxal and AGE in mycobacteria-induced macrophage apoptosis and activation.

Critical role of methylglyoxal and AGE in mycobacteria-induced macrophage apoptosis and activation.

Apoptosis and activation of macrophages play an important role in the host response to mycobacterial infection involving TNF-alpha as a critical autocrine mediator. The underlying mechanisms are still ill-defined. Here, we demonstrate elevated levels of methylglyoxal (MG), a small and reactive molec...

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Bibliographic Details
Main Authors: Helmy Rachman, Nayoung Kim, Timo Ulrichs, Sven Baumann, Lydia Pradl, Ali Nasser Eddine, Matthias Bild, Marion Rother, Ralf-Jürgen Kuban, Jong Seok Lee, Robert Hurwitz, Volker Brinkmann, George A Kosmiadi, Stefan H E Kaufmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1762319?pdf=render

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http://europepmc.org/articles/PMC1762319?pdf=render

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