Characterization of essential domains in HSD17B13 for cellular localization and enzymatic activity

Characterization of essential domains in HSD17B13 for cellular localization and enzymatic activity

Human genetic studies recently identified an association of SNPs in the 17-β hydroxysteroid dehydrogenase 13 (HSD17B13) gene with alcoholic and nonalcoholic fatty liver disease development. Mutant HSD17B13 variants devoid of enzymatic function have been demonstrated to be protective from cirrhosis a...

Full description

Bibliographic Details
Main Authors: Yanling Ma, Suman Karki, Philip M. Brown, Dennis D. Lin, Maren C. Podszun, Wenchang Zhou, Olga V. Belyaeva, Natalia Y. Kedishvili, Yaron Rotman
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Journal of Lipid Research
Subjects:
nonalcoholic fatty liver disease
alcoholic liver disease
retinoids
lipid droplets
enzyme regulation
protein structure
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520437289

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520437289

Similar Items