Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation

Sarcopenia, defined as the age-related decrease in muscle mass, strength and physical performance, is associated with reduced bone mass and elevated low-grade inflammation. From a healthy aging perspective, interventions which overcome sarcopenia are clinically relevant. Accumulating evidence sugges...

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Main Authors:	Darren G. Candow, Scott C. Forbes, Philip D. Chilibeck, Stephen M. Cornish, Jose Antonio, Richard B. Kreider
Format:	Article
Language:	English
Published:	MDPI AG 2019-04-01
Series:	Journal of Clinical Medicine
Subjects:	sarcopenia dynapenia mechanisms exercise functionality safety
Online Access:	https://www.mdpi.com/2077-0383/8/4/488

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spelling	doaj-60f8aef05d97466ca46ef00a3a1581582020-11-25T00:56:22ZengMDPI AGJournal of Clinical Medicine2077-03832019-04-018448810.3390/jcm8040488jcm8040488Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and InflammationDarren G. Candow0Scott C. Forbes1Philip D. Chilibeck2Stephen M. Cornish3Jose Antonio4Richard B. Kreider5Faculty of Kinesiology and Health Studies, University of Regina, Regina, SK S4S 0A2, CanadaDepartment of Physical Education, Brandon University, Brandon, MB R7A 6A9, CanadaCollege of Kinesiology, University of Saskatchewan, Saskatoon, SK S7N 5B2, CanadaFaculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB R3T 2N2, CanadaDepartment of Health and Human Performance, Nova Southeastern University, Davie, FL 33314, USADepartment of Health and Kinesiology, Texas A&M University, College Station, TX 77843-4253, USASarcopenia, defined as the age-related decrease in muscle mass, strength and physical performance, is associated with reduced bone mass and elevated low-grade inflammation. From a healthy aging perspective, interventions which overcome sarcopenia are clinically relevant. Accumulating evidence suggests that exogenous creatine supplementation has the potential to increase aging muscle mass, muscle performance, and decrease the risk of falls and possibly attenuate inflammation and loss of bone mineral. Therefore, the purpose of this review is to: (1) summarize the effects of creatine supplementation, with and without resistance training, in aging adults and discuss possible mechanisms of action, (2) examine the effects of creatine on bone biology and risk of falls, (3) evaluate the potential anti-inflammatory effects of creatine and (4) determine the safety of creatine supplementation in aging adults.https://www.mdpi.com/2077-0383/8/4/488sarcopeniadynapeniamechanismsexercisefunctionalitysafety
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Darren G. Candow Scott C. Forbes Philip D. Chilibeck Stephen M. Cornish Jose Antonio Richard B. Kreider
spellingShingle	Darren G. Candow Scott C. Forbes Philip D. Chilibeck Stephen M. Cornish Jose Antonio Richard B. Kreider Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation Journal of Clinical Medicine sarcopenia dynapenia mechanisms exercise functionality safety
author_facet	Darren G. Candow Scott C. Forbes Philip D. Chilibeck Stephen M. Cornish Jose Antonio Richard B. Kreider
author_sort	Darren G. Candow
title	Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation
title_short	Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation
title_full	Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation
title_fullStr	Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation
title_full_unstemmed	Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation
title_sort	effectiveness of creatine supplementation on aging muscle and bone: focus on falls prevention and inflammation
publisher	MDPI AG
series	Journal of Clinical Medicine
issn	2077-0383
publishDate	2019-04-01
description	Sarcopenia, defined as the age-related decrease in muscle mass, strength and physical performance, is associated with reduced bone mass and elevated low-grade inflammation. From a healthy aging perspective, interventions which overcome sarcopenia are clinically relevant. Accumulating evidence suggests that exogenous creatine supplementation has the potential to increase aging muscle mass, muscle performance, and decrease the risk of falls and possibly attenuate inflammation and loss of bone mineral. Therefore, the purpose of this review is to: (1) summarize the effects of creatine supplementation, with and without resistance training, in aging adults and discuss possible mechanisms of action, (2) examine the effects of creatine on bone biology and risk of falls, (3) evaluate the potential anti-inflammatory effects of creatine and (4) determine the safety of creatine supplementation in aging adults.
topic	sarcopenia dynapenia mechanisms exercise functionality safety
url	https://www.mdpi.com/2077-0383/8/4/488
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Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation

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