HIF-1α Mediates TRAIL-Induced Neuronal Apoptosis via Regulating DcR1 Expression Following Traumatic Brain Injury

HIF-1α Mediates TRAIL-Induced Neuronal Apoptosis via Regulating DcR1 Expression Following Traumatic Brain Injury

Background: Neuronal apoptosis involved in secondary injury following traumatic brain injury (TBI) significantly contributes to the poor outcomes of patients with TBI. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis of tumor cells. Hypoxia factor...

Full description

Bibliographic Details
Main Authors: Yuanjian Fang, Jianan Lu, Xiaoyu Wang, Haijian Wu, Shuhao Mei, Jingwei Zheng, Shenbin Xu, Cameron Lenahan, Sheng Chen, Jianmin Zhang, Yuan Hong
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
traumatic brain injury
tumor necrosis factor-related apoptosis-inducing ligand
death receptor 5
decoy receptor
hypoxia-induced factor-1α
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00192/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00192/full

Similar Items