Mechanisms of Takotsubo Cardiomyopathy; Role of Microcirculatory Dysfunction

Takotsubo cardiomyopathy is characterized by reversible left ventricular dysfunction, typically preceded by an emotional or a physical stressor. The underlying pathophysiologic mechanisms include multivessel coronary vascular spasm, microvascular dysfunction, neurogenic stunning of the myocardium an...

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Main Authors: Nauman Khalid, Sarah Aftab Ahmad, Affan Umer
Format: Article
Language:English
Published: Barcaray International 2016-01-01
Series:International Cardiovascular Forum Journal
Subjects:
Online Access:http://icfjournal.org/index.php/icfj/article/view/237/pdf-2
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spelling doaj-613bf63a7f3b401d8ecb76397528ef782020-11-24T23:45:21ZengBarcaray InternationalInternational Cardiovascular Forum Journal2410-26362409-34242016-01-0153032https://doi.org/10.17987/icfj.v5i0.237Mechanisms of Takotsubo Cardiomyopathy; Role of Microcirculatory DysfunctionNauman Khalid0Sarah Aftab Ahmad1Affan Umer2Saint Louis University School of Medicine, St. Louis, MO, USATexas Tech University Health Science Center,, Lubbock, TX, USAUniversity of Connecticut School of Medicine, Hartford, CT, USATakotsubo cardiomyopathy is characterized by reversible left ventricular dysfunction, typically preceded by an emotional or a physical stressor. The underlying pathophysiologic mechanisms include multivessel coronary vascular spasm, microvascular dysfunction, neurogenic stunning of the myocardium and catecholamine surge. Microcirculatory dysfunction may play a key role in the evolution of this syndrome especially in the acute phases of the illness. Severe invasive and noninvasive modalities are utilized to ascertain any compromise in coronary perfusion in Takotsubo cardiomyopathy, including Doppler guidewire technique, Thrombolysis in myocardial infarction (TIMI) frame count (TFC), TIMI myocardial perfusion grade (TMPG) and nuclear imaging techniques. TIMI frame count can be utilized as a diagnostic marker and clinical indicator in assessment of microvascular function or coronary flow in patients with Takotsubo cardiomyopathy.http://icfjournal.org/index.php/icfj/article/view/237/pdf-2Takotsubo cardiomyopathyMicrovascular dysfunctionTIMI frame countCoronary flow reserveMicrocirculatory disorder
collection DOAJ
language English
format Article
sources DOAJ
author Nauman Khalid
Sarah Aftab Ahmad
Affan Umer
spellingShingle Nauman Khalid
Sarah Aftab Ahmad
Affan Umer
Mechanisms of Takotsubo Cardiomyopathy; Role of Microcirculatory Dysfunction
International Cardiovascular Forum Journal
Takotsubo cardiomyopathy
Microvascular dysfunction
TIMI frame count
Coronary flow reserve
Microcirculatory disorder
author_facet Nauman Khalid
Sarah Aftab Ahmad
Affan Umer
author_sort Nauman Khalid
title Mechanisms of Takotsubo Cardiomyopathy; Role of Microcirculatory Dysfunction
title_short Mechanisms of Takotsubo Cardiomyopathy; Role of Microcirculatory Dysfunction
title_full Mechanisms of Takotsubo Cardiomyopathy; Role of Microcirculatory Dysfunction
title_fullStr Mechanisms of Takotsubo Cardiomyopathy; Role of Microcirculatory Dysfunction
title_full_unstemmed Mechanisms of Takotsubo Cardiomyopathy; Role of Microcirculatory Dysfunction
title_sort mechanisms of takotsubo cardiomyopathy; role of microcirculatory dysfunction
publisher Barcaray International
series International Cardiovascular Forum Journal
issn 2410-2636
2409-3424
publishDate 2016-01-01
description Takotsubo cardiomyopathy is characterized by reversible left ventricular dysfunction, typically preceded by an emotional or a physical stressor. The underlying pathophysiologic mechanisms include multivessel coronary vascular spasm, microvascular dysfunction, neurogenic stunning of the myocardium and catecholamine surge. Microcirculatory dysfunction may play a key role in the evolution of this syndrome especially in the acute phases of the illness. Severe invasive and noninvasive modalities are utilized to ascertain any compromise in coronary perfusion in Takotsubo cardiomyopathy, including Doppler guidewire technique, Thrombolysis in myocardial infarction (TIMI) frame count (TFC), TIMI myocardial perfusion grade (TMPG) and nuclear imaging techniques. TIMI frame count can be utilized as a diagnostic marker and clinical indicator in assessment of microvascular function or coronary flow in patients with Takotsubo cardiomyopathy.
topic Takotsubo cardiomyopathy
Microvascular dysfunction
TIMI frame count
Coronary flow reserve
Microcirculatory disorder
url http://icfjournal.org/index.php/icfj/article/view/237/pdf-2
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