Mechanisms of Takotsubo Cardiomyopathy; Role of Microcirculatory Dysfunction
Takotsubo cardiomyopathy is characterized by reversible left ventricular dysfunction, typically preceded by an emotional or a physical stressor. The underlying pathophysiologic mechanisms include multivessel coronary vascular spasm, microvascular dysfunction, neurogenic stunning of the myocardium an...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Barcaray International
2016-01-01
|
Series: | International Cardiovascular Forum Journal |
Subjects: | |
Online Access: | http://icfjournal.org/index.php/icfj/article/view/237/pdf-2 |
id |
doaj-613bf63a7f3b401d8ecb76397528ef78 |
---|---|
record_format |
Article |
spelling |
doaj-613bf63a7f3b401d8ecb76397528ef782020-11-24T23:45:21ZengBarcaray InternationalInternational Cardiovascular Forum Journal2410-26362409-34242016-01-0153032https://doi.org/10.17987/icfj.v5i0.237Mechanisms of Takotsubo Cardiomyopathy; Role of Microcirculatory DysfunctionNauman Khalid0Sarah Aftab Ahmad1Affan Umer2Saint Louis University School of Medicine, St. Louis, MO, USATexas Tech University Health Science Center,, Lubbock, TX, USAUniversity of Connecticut School of Medicine, Hartford, CT, USATakotsubo cardiomyopathy is characterized by reversible left ventricular dysfunction, typically preceded by an emotional or a physical stressor. The underlying pathophysiologic mechanisms include multivessel coronary vascular spasm, microvascular dysfunction, neurogenic stunning of the myocardium and catecholamine surge. Microcirculatory dysfunction may play a key role in the evolution of this syndrome especially in the acute phases of the illness. Severe invasive and noninvasive modalities are utilized to ascertain any compromise in coronary perfusion in Takotsubo cardiomyopathy, including Doppler guidewire technique, Thrombolysis in myocardial infarction (TIMI) frame count (TFC), TIMI myocardial perfusion grade (TMPG) and nuclear imaging techniques. TIMI frame count can be utilized as a diagnostic marker and clinical indicator in assessment of microvascular function or coronary flow in patients with Takotsubo cardiomyopathy.http://icfjournal.org/index.php/icfj/article/view/237/pdf-2Takotsubo cardiomyopathyMicrovascular dysfunctionTIMI frame countCoronary flow reserveMicrocirculatory disorder |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nauman Khalid Sarah Aftab Ahmad Affan Umer |
spellingShingle |
Nauman Khalid Sarah Aftab Ahmad Affan Umer Mechanisms of Takotsubo Cardiomyopathy; Role of Microcirculatory Dysfunction International Cardiovascular Forum Journal Takotsubo cardiomyopathy Microvascular dysfunction TIMI frame count Coronary flow reserve Microcirculatory disorder |
author_facet |
Nauman Khalid Sarah Aftab Ahmad Affan Umer |
author_sort |
Nauman Khalid |
title |
Mechanisms of Takotsubo Cardiomyopathy; Role of Microcirculatory Dysfunction |
title_short |
Mechanisms of Takotsubo Cardiomyopathy; Role of Microcirculatory Dysfunction |
title_full |
Mechanisms of Takotsubo Cardiomyopathy; Role of Microcirculatory Dysfunction |
title_fullStr |
Mechanisms of Takotsubo Cardiomyopathy; Role of Microcirculatory Dysfunction |
title_full_unstemmed |
Mechanisms of Takotsubo Cardiomyopathy; Role of Microcirculatory Dysfunction |
title_sort |
mechanisms of takotsubo cardiomyopathy; role of microcirculatory dysfunction |
publisher |
Barcaray International |
series |
International Cardiovascular Forum Journal |
issn |
2410-2636 2409-3424 |
publishDate |
2016-01-01 |
description |
Takotsubo cardiomyopathy is characterized by reversible left ventricular dysfunction, typically preceded by an emotional or a physical stressor. The underlying pathophysiologic mechanisms include multivessel coronary vascular spasm, microvascular dysfunction, neurogenic stunning of the myocardium and catecholamine surge. Microcirculatory dysfunction may play a key role in the evolution of this syndrome especially in the acute phases of the illness. Severe invasive and noninvasive modalities are utilized to ascertain any compromise in coronary perfusion in Takotsubo cardiomyopathy, including Doppler guidewire technique, Thrombolysis in myocardial infarction (TIMI) frame count (TFC), TIMI myocardial perfusion grade (TMPG) and nuclear imaging techniques. TIMI frame count can be utilized as a diagnostic marker and clinical indicator in assessment of microvascular function or coronary flow in patients with Takotsubo cardiomyopathy. |
topic |
Takotsubo cardiomyopathy Microvascular dysfunction TIMI frame count Coronary flow reserve Microcirculatory disorder |
url |
http://icfjournal.org/index.php/icfj/article/view/237/pdf-2 |
work_keys_str_mv |
AT naumankhalid mechanismsoftakotsubocardiomyopathyroleofmicrocirculatorydysfunction AT sarahaftabahmad mechanismsoftakotsubocardiomyopathyroleofmicrocirculatorydysfunction AT affanumer mechanismsoftakotsubocardiomyopathyroleofmicrocirculatorydysfunction |
_version_ |
1725496068021420032 |