Targeting the Sonic Hedgehog Pathway to Suppress the Expression of the Cancer Stem Cell (CSC)—Related Transcription Factors and CSC-Driven Thyroid Tumor Growth

Targeting the Sonic Hedgehog Pathway to Suppress the Expression of the Cancer Stem Cell (CSC)—Related Transcription Factors and CSC-Driven Thyroid Tumor Growth

The sonic hedgehog (Shh) pathway plays important roles in tumorigenesis, tumor growth, drug resistance, and metastasis. We and others have reported earlier that this pathway is highly activated in thyroid cancer. However, its role in thyroid cancer stem cell (CSC) self-renewal and tumor development...

Full description

Bibliographic Details
Main Authors: Yurong Lu, Yiwen Zhu, Shihan Deng, Yuhuang Chen, Wei Li, Jing Sun, Xiulong Xu
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
thyroid cancer
BMI1
SOX 2
sonic hedgehog
Gli1
Snail
Online Access:https://www.mdpi.com/2072-6694/13/3/418

Internet

https://www.mdpi.com/2072-6694/13/3/418

Similar Items