Prediction of the changes in drug dissolution from an immediate-release tablet containing two active pharmaceutical ingredients using an accelerated stability assessment program (ASAPprime®)

Prediction of the changes in drug dissolution from an immediate-release tablet containing two active pharmaceutical ingredients using an accelerated stability assessment program (ASAPprime®)

Abstract The computer program ASAPprime® has been used successfully for some time to predict the stability of active pharmaceutical ingredients (APIs) in solid-dosage forms. In this study, we have demonstrated that the ASAPprime® program can also be used to predict the slow-down in dissolution of tw...

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Bibliographic Details
Main Authors: Hanlin Li, David Nadig, Andrew Kuzmission, Christopher M. Riley
Format: Article
Language:English
Published: SpringerOpen 2016-11-01
Series:AAPS Open
Subjects:
Accelerated stability
Accelerated stability assessment program (ASAPprime®)
Arrhenius relationship
Dissolution
Stability prediction
Temperature effects
Online Access:http://link.springer.com/article/10.1186/s41120-016-0010-5

Internet

http://link.springer.com/article/10.1186/s41120-016-0010-5

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