Median Lethal Dose, Antimalarial Activity, Phytochemical Screening and Radical Scavenging of Methanolic Languas galanga Rhizome Extract

The methanolic extract of Languas galanga rhizomes was investigated for antimalarial activity against Plasmodium berghei (NK65) infections in mice. The median lethal dose was determined to ascertain the safety of the extract in ICR mice of both sexes. The antimalarial activities during early and est...

Full description

Bibliographic Details
Main Authors: Abdulelah H. Al-Adhroey, Zurainee M. Nor, Rohela Mahmud, Hesham M. Al-Mekhlafi
Format: Article
Language:English
Published: MDPI AG 2010-11-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/15/11/8366/
id doaj-61a60d5cfa384b668e4959110f4574b4
record_format Article
spelling doaj-61a60d5cfa384b668e4959110f4574b42020-11-24T23:39:02ZengMDPI AGMolecules1420-30492010-11-0115118366837610.3390/molecules15118366Median Lethal Dose, Antimalarial Activity, Phytochemical Screening and Radical Scavenging of Methanolic Languas galanga Rhizome ExtractAbdulelah H. Al-AdhroeyZurainee M. NorRohela MahmudHesham M. Al-MekhlafiThe methanolic extract of Languas galanga rhizomes was investigated for antimalarial activity against Plasmodium berghei (NK65) infections in mice. The median lethal dose was determined to ascertain the safety of the extract in ICR mice of both sexes. The antimalarial activities during early and established infections, as well as the prophylactic activity were evaluated. Phytochemical screening and radical scavenging activity of the extract were also investigated to elucidate the possible mechanism of the antimalarial properties. The acute oral toxicity (LD50) of Languas galanga extract in mice was established to be 4,998 mg/kg. The extract of Languas galanga rhizomes demonstrated significant antiplasmodial activity in all the three models of the antimalarial evaluations. Phytochemical screening revealed the presence of some vital antiplasmodial constituents such as terpenoids and flavonoids. The extract also exhibited a moderate capacity to scavenge the free radicals. The rhizome extract of Languas galanga thus possesses antimalarial activity, which explains the rational usage of this plant in traditional Malaysian medicine. http://www.mdpi.com/1420-3049/15/11/8366/Languas galangamethanolic extractantimalarial activity
collection DOAJ
language English
format Article
sources DOAJ
author Abdulelah H. Al-Adhroey
Zurainee M. Nor
Rohela Mahmud
Hesham M. Al-Mekhlafi
spellingShingle Abdulelah H. Al-Adhroey
Zurainee M. Nor
Rohela Mahmud
Hesham M. Al-Mekhlafi
Median Lethal Dose, Antimalarial Activity, Phytochemical Screening and Radical Scavenging of Methanolic Languas galanga Rhizome Extract
Molecules
Languas galanga
methanolic extract
antimalarial activity
author_facet Abdulelah H. Al-Adhroey
Zurainee M. Nor
Rohela Mahmud
Hesham M. Al-Mekhlafi
author_sort Abdulelah H. Al-Adhroey
title Median Lethal Dose, Antimalarial Activity, Phytochemical Screening and Radical Scavenging of Methanolic Languas galanga Rhizome Extract
title_short Median Lethal Dose, Antimalarial Activity, Phytochemical Screening and Radical Scavenging of Methanolic Languas galanga Rhizome Extract
title_full Median Lethal Dose, Antimalarial Activity, Phytochemical Screening and Radical Scavenging of Methanolic Languas galanga Rhizome Extract
title_fullStr Median Lethal Dose, Antimalarial Activity, Phytochemical Screening and Radical Scavenging of Methanolic Languas galanga Rhizome Extract
title_full_unstemmed Median Lethal Dose, Antimalarial Activity, Phytochemical Screening and Radical Scavenging of Methanolic Languas galanga Rhizome Extract
title_sort median lethal dose, antimalarial activity, phytochemical screening and radical scavenging of methanolic languas galanga rhizome extract
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2010-11-01
description The methanolic extract of Languas galanga rhizomes was investigated for antimalarial activity against Plasmodium berghei (NK65) infections in mice. The median lethal dose was determined to ascertain the safety of the extract in ICR mice of both sexes. The antimalarial activities during early and established infections, as well as the prophylactic activity were evaluated. Phytochemical screening and radical scavenging activity of the extract were also investigated to elucidate the possible mechanism of the antimalarial properties. The acute oral toxicity (LD50) of Languas galanga extract in mice was established to be 4,998 mg/kg. The extract of Languas galanga rhizomes demonstrated significant antiplasmodial activity in all the three models of the antimalarial evaluations. Phytochemical screening revealed the presence of some vital antiplasmodial constituents such as terpenoids and flavonoids. The extract also exhibited a moderate capacity to scavenge the free radicals. The rhizome extract of Languas galanga thus possesses antimalarial activity, which explains the rational usage of this plant in traditional Malaysian medicine.
topic Languas galanga
methanolic extract
antimalarial activity
url http://www.mdpi.com/1420-3049/15/11/8366/
work_keys_str_mv AT abdulelahhaladhroey medianlethaldoseantimalarialactivityphytochemicalscreeningandradicalscavengingofmethanoliclanguasgalangarhizomeextract
AT zuraineemnor medianlethaldoseantimalarialactivityphytochemicalscreeningandradicalscavengingofmethanoliclanguasgalangarhizomeextract
AT rohelamahmud medianlethaldoseantimalarialactivityphytochemicalscreeningandradicalscavengingofmethanoliclanguasgalangarhizomeextract
AT heshammalmekhlafi medianlethaldoseantimalarialactivityphytochemicalscreeningandradicalscavengingofmethanoliclanguasgalangarhizomeextract
_version_ 1725515011861774336