Incorporation of drug efflux inhibitor and chemotherapeutic agent into an inorganic/organic platform for the effective treatment of multidrug resistant breast cancer

Abstract Background Multidrug resistance (MDR) is a pressing obstacle in clinical chemotherapy for breast cancer. Based on the fact that the drug efflux is an important factor in MDR, we designed a codelivery system to guide the drug efflux inhibitor verapamil (VRP) and the chemotherapeutic agent no...

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Bibliographic Details
Main Authors: Yang Dong, Hongze Liao, Jian Yu, Hao Fu, De Zhao, Ke Gong, Qi Wang, Yourong Duan
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Nanobiotechnology
Subjects:
MDR
Online Access:https://doi.org/10.1186/s12951-019-0559-y