Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis
The single-cell gene expression changes during spinal cord formation and neurogenesis in mice are unclear. Here, the authors use a HES5 reporter to live image, then mathematically model, oscillations in single cells in presumed progenitors and neurons of the developing spinal cord.
Main Authors: | Cerys S. Manning, Veronica Biga, James Boyd, Jochen Kursawe, Bodvar Ymisson, David G. Spiller, Christopher M. Sanderson, Tobias Galla, Magnus Rattray, Nancy Papalopulu |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-06-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-10734-8 |
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