Lifetime psychopathology among the offspring of Bipolar I parents
BACKGROUND: Recent studies have demonstrated high rates of psychopathology in the offspring of parents with bipolar disorder. The aim of this study was to identify psychiatric diagnoses in a sample of children of bipolar parents. METHOD: This case series comprised 35 children and adolescents aged 6...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Faculdade de Medicina / USP
2011-01-01
|
Series: | Clinics |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000500003 |
id |
doaj-62797aa0519f428ea83b8b1e6534bed1 |
---|---|
record_format |
Article |
spelling |
doaj-62797aa0519f428ea83b8b1e6534bed12020-11-25T00:17:34ZengFaculdade de Medicina / USPClinics1807-59321980-53222011-01-0166572573010.1590/S1807-59322011000500003Lifetime psychopathology among the offspring of Bipolar I parentsMarcelo C. ZappitelliIsabel A. BordinJohn P. HatchSheila C. CaetanoGiovana Zunta-SoaresRene L. OlveraJair C. SoaresBACKGROUND: Recent studies have demonstrated high rates of psychopathology in the offspring of parents with bipolar disorder. The aim of this study was to identify psychiatric diagnoses in a sample of children of bipolar parents. METHOD: This case series comprised 35 children and adolescents aged 6 to 17 years, with a mean age of 12.5 + 2.9 years (20 males and 15 females), who had at least one parent with bipolar disorder type I. The subjects were assessed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime version (K-SADS-PL). Family psychiatric history and demographics were also evaluated. RESULTS: Of the offspring studied, 71.4% had a lifetime diagnosis of at least one psychiatric disorder (28.6% with a mood disorder, 40% with a disruptive behavior disorder and 20% with an anxiety disorder). Pure mood disorders (11.4%) occurred less frequently than mood disorders comorbid with attention deficit hyperactivity disorder (17.1%). Psychopathology was commonly reported in second-degree relatives of the offspring of parents with bipolar disorder (71.4%). CONCLUSIONS: Our results support previous findings of an increased risk for developing psychopathology, predominantly mood and disruptive disorders, in the offspring of bipolar individuals. Prospective studies with larger samples are needed to confirm and expand these results.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000500003Bipolar DisorderOffspringPsychopathologyChildAdolescent |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marcelo C. Zappitelli Isabel A. Bordin John P. Hatch Sheila C. Caetano Giovana Zunta-Soares Rene L. Olvera Jair C. Soares |
spellingShingle |
Marcelo C. Zappitelli Isabel A. Bordin John P. Hatch Sheila C. Caetano Giovana Zunta-Soares Rene L. Olvera Jair C. Soares Lifetime psychopathology among the offspring of Bipolar I parents Clinics Bipolar Disorder Offspring Psychopathology Child Adolescent |
author_facet |
Marcelo C. Zappitelli Isabel A. Bordin John P. Hatch Sheila C. Caetano Giovana Zunta-Soares Rene L. Olvera Jair C. Soares |
author_sort |
Marcelo C. Zappitelli |
title |
Lifetime psychopathology among the offspring of Bipolar I parents |
title_short |
Lifetime psychopathology among the offspring of Bipolar I parents |
title_full |
Lifetime psychopathology among the offspring of Bipolar I parents |
title_fullStr |
Lifetime psychopathology among the offspring of Bipolar I parents |
title_full_unstemmed |
Lifetime psychopathology among the offspring of Bipolar I parents |
title_sort |
lifetime psychopathology among the offspring of bipolar i parents |
publisher |
Faculdade de Medicina / USP |
series |
Clinics |
issn |
1807-5932 1980-5322 |
publishDate |
2011-01-01 |
description |
BACKGROUND: Recent studies have demonstrated high rates of psychopathology in the offspring of parents with bipolar disorder. The aim of this study was to identify psychiatric diagnoses in a sample of children of bipolar parents. METHOD: This case series comprised 35 children and adolescents aged 6 to 17 years, with a mean age of 12.5 + 2.9 years (20 males and 15 females), who had at least one parent with bipolar disorder type I. The subjects were assessed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime version (K-SADS-PL). Family psychiatric history and demographics were also evaluated. RESULTS: Of the offspring studied, 71.4% had a lifetime diagnosis of at least one psychiatric disorder (28.6% with a mood disorder, 40% with a disruptive behavior disorder and 20% with an anxiety disorder). Pure mood disorders (11.4%) occurred less frequently than mood disorders comorbid with attention deficit hyperactivity disorder (17.1%). Psychopathology was commonly reported in second-degree relatives of the offspring of parents with bipolar disorder (71.4%). CONCLUSIONS: Our results support previous findings of an increased risk for developing psychopathology, predominantly mood and disruptive disorders, in the offspring of bipolar individuals. Prospective studies with larger samples are needed to confirm and expand these results. |
topic |
Bipolar Disorder Offspring Psychopathology Child Adolescent |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000500003 |
work_keys_str_mv |
AT marceloczappitelli lifetimepsychopathologyamongtheoffspringofbipolariparents AT isabelabordin lifetimepsychopathologyamongtheoffspringofbipolariparents AT johnphatch lifetimepsychopathologyamongtheoffspringofbipolariparents AT sheilaccaetano lifetimepsychopathologyamongtheoffspringofbipolariparents AT giovanazuntasoares lifetimepsychopathologyamongtheoffspringofbipolariparents AT renelolvera lifetimepsychopathologyamongtheoffspringofbipolariparents AT jaircsoares lifetimepsychopathologyamongtheoffspringofbipolariparents |
_version_ |
1725379226385776640 |