Effects of Protein Supplementation Combined with Exercise Training on Muscle Mass and Function in Older Adults with Lower-Extremity Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Trials
Aging and osteoarthritis (OA) are associated with a high risk of muscle mass loss, which can lead to physical disability. This study investigated the effectiveness of protein supplementation combined with exercise training (PS + ET) in improving muscle mass and functional outcomes in older adults wi...
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doaj-62dc7c93d79b466bb4be5cf2ddc487f92020-11-25T03:27:17ZengMDPI AGNutrients2072-66432020-08-01122422242210.3390/nu12082422Effects of Protein Supplementation Combined with Exercise Training on Muscle Mass and Function in Older Adults with Lower-Extremity Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized TrialsChun-De Liao0Yen-Tzu Wu1Jau-Yih Tsauo2Pey-Rong Chen3Yu-Kang Tu4Hung-Chou Chen5Tsan-Hon Liou6School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei 100025, TaiwanSchool and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei 100025, TaiwanSchool and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei 100025, TaiwanDepartment of Dietetics, National Taiwan University Hospital, Taipei 100225, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 100025, TaiwanDepartment of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235041, TaiwanDepartment of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235041, TaiwanAging and osteoarthritis (OA) are associated with a high risk of muscle mass loss, which can lead to physical disability. This study investigated the effectiveness of protein supplementation combined with exercise training (PS + ET) in improving muscle mass and functional outcomes in older adults with lower-limb OA. A comprehensive search of online databases was performed to identify randomized controlled trials (RCTs) on the effectiveness of PS + ET in older adults with hip or knee OA. Meta-analysis and risk of bias assessment of the included RCTs were conducted. Six RCTs were included in this systemic review; they had a median (range/total) Physiotherapy Evidence Database (PEDro) score of 7 (6–9) out of 10, respectively. Five RCTs that enrolled patients who underwent total joint replacement were included in this meta-analysis. The PS + ET group exhibited significant improvements in muscle mass (standard mean difference [SMD] = 1.13, <i>p</i> < 0.00001), pain (SMD = 1.36, <i>p</i> < 0.00001), and muscle strength (SMD = 0.44, <i>p</i> = 0.04). Our findings suggest that PS + ET improves muscle mass, muscle strength, and functional outcomes and reduces pain in older adults with lower-limb OA, particularly in those who have undergone total joint replacement.https://www.mdpi.com/2072-6643/12/8/2422osteoarthritissarcopeniaarthroplastyprotein supplementexercise trainingmuscle mass |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chun-De Liao Yen-Tzu Wu Jau-Yih Tsauo Pey-Rong Chen Yu-Kang Tu Hung-Chou Chen Tsan-Hon Liou |
spellingShingle |
Chun-De Liao Yen-Tzu Wu Jau-Yih Tsauo Pey-Rong Chen Yu-Kang Tu Hung-Chou Chen Tsan-Hon Liou Effects of Protein Supplementation Combined with Exercise Training on Muscle Mass and Function in Older Adults with Lower-Extremity Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Trials Nutrients osteoarthritis sarcopenia arthroplasty protein supplement exercise training muscle mass |
author_facet |
Chun-De Liao Yen-Tzu Wu Jau-Yih Tsauo Pey-Rong Chen Yu-Kang Tu Hung-Chou Chen Tsan-Hon Liou |
author_sort |
Chun-De Liao |
title |
Effects of Protein Supplementation Combined with Exercise Training on Muscle Mass and Function in Older Adults with Lower-Extremity Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Trials |
title_short |
Effects of Protein Supplementation Combined with Exercise Training on Muscle Mass and Function in Older Adults with Lower-Extremity Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Trials |
title_full |
Effects of Protein Supplementation Combined with Exercise Training on Muscle Mass and Function in Older Adults with Lower-Extremity Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Trials |
title_fullStr |
Effects of Protein Supplementation Combined with Exercise Training on Muscle Mass and Function in Older Adults with Lower-Extremity Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Trials |
title_full_unstemmed |
Effects of Protein Supplementation Combined with Exercise Training on Muscle Mass and Function in Older Adults with Lower-Extremity Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Trials |
title_sort |
effects of protein supplementation combined with exercise training on muscle mass and function in older adults with lower-extremity osteoarthritis: a systematic review and meta-analysis of randomized trials |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2020-08-01 |
description |
Aging and osteoarthritis (OA) are associated with a high risk of muscle mass loss, which can lead to physical disability. This study investigated the effectiveness of protein supplementation combined with exercise training (PS + ET) in improving muscle mass and functional outcomes in older adults with lower-limb OA. A comprehensive search of online databases was performed to identify randomized controlled trials (RCTs) on the effectiveness of PS + ET in older adults with hip or knee OA. Meta-analysis and risk of bias assessment of the included RCTs were conducted. Six RCTs were included in this systemic review; they had a median (range/total) Physiotherapy Evidence Database (PEDro) score of 7 (6–9) out of 10, respectively. Five RCTs that enrolled patients who underwent total joint replacement were included in this meta-analysis. The PS + ET group exhibited significant improvements in muscle mass (standard mean difference [SMD] = 1.13, <i>p</i> < 0.00001), pain (SMD = 1.36, <i>p</i> < 0.00001), and muscle strength (SMD = 0.44, <i>p</i> = 0.04). Our findings suggest that PS + ET improves muscle mass, muscle strength, and functional outcomes and reduces pain in older adults with lower-limb OA, particularly in those who have undergone total joint replacement. |
topic |
osteoarthritis sarcopenia arthroplasty protein supplement exercise training muscle mass |
url |
https://www.mdpi.com/2072-6643/12/8/2422 |
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