Henoch-Schönlein Purpura: A Literature Review
Henoch-Schönlein purpura is the most common childhood vasculitis, but may also affect adults. This article reviews the literature since 2011 on advances in diagnosis, clinical disease manifestations, pathophysiology and treatment of Henoch-Schönlein purpura. The clinical manifestations are thought t...
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Society for Publication of Acta Dermato-Venereologica
2017-08-01
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https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2733
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doaj-6307ac6f74c14049a76feec0bf4984f72020-11-24T23:17:08ZengSociety for Publication of Acta Dermato-VenereologicaActa Dermato-Venereologica0001-55551651-20572017-08-0197101160116610.2340/00015555-27335010Henoch-Schönlein Purpura: A Literature ReviewLiv Eline Hetland0Kjærsti Sørensen SusrudKim Hein LindahlAnette Bygum Faculty of Health Sciences, University of Southern Denmark, Research Unit of Dermato-venerology and Allergycentre, J.B. Winsløws Vej 2C, DK-5000 Odense C, Denmark. livelinehetland@gmail.com. Henoch-Schönlein purpura is the most common childhood vasculitis, but may also affect adults. This article reviews the literature since 2011 on advances in diagnosis, clinical disease manifestations, pathophysiology and treatment of Henoch-Schönlein purpura. The clinical manifestations are thought to arise from IgA depositions in blood vessel walls in the affected organs, mostly skin, gastrointestinal tract, joints and kidneys. Corticosteroids may be effective in rapid resolution of renal manifestations and treating joint and abdominal pain, but they are not proven effective for treating organ manifestations and complications, such as glomerulonephritis, bowel infarction or intussusception. Mycophenolate mofetil or cyclosporine A may be better treatment choices in case of renal involvement. Other immunosuppressive and immunomodulating drugs, such as rituximab and dapsone, are promising, but larger studies are needed to confirm these findings. Cancer screening should be considered in older males diagnosed with Henoch-Schönlein purpura. https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2733 Henoch-SchönleinpurpuravasculitisimmunoglobulinAcorticosteroids |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Liv Eline Hetland Kjærsti Sørensen Susrud Kim Hein Lindahl Anette Bygum |
spellingShingle |
Liv Eline Hetland Kjærsti Sørensen Susrud Kim Hein Lindahl Anette Bygum Henoch-Schönlein Purpura: A Literature Review Acta Dermato-Venereologica Henoch-Schönleinpurpura vasculitis immunoglobulinA corticosteroids |
author_facet |
Liv Eline Hetland Kjærsti Sørensen Susrud Kim Hein Lindahl Anette Bygum |
author_sort |
Liv Eline Hetland |
title |
Henoch-Schönlein Purpura: A Literature Review |
title_short |
Henoch-Schönlein Purpura: A Literature Review |
title_full |
Henoch-Schönlein Purpura: A Literature Review |
title_fullStr |
Henoch-Schönlein Purpura: A Literature Review |
title_full_unstemmed |
Henoch-Schönlein Purpura: A Literature Review |
title_sort |
henoch-schönlein purpura: a literature review |
publisher |
Society for Publication of Acta Dermato-Venereologica |
series |
Acta Dermato-Venereologica |
issn |
0001-5555 1651-2057 |
publishDate |
2017-08-01 |
description |
Henoch-Schönlein purpura is the most common childhood vasculitis, but may also affect adults. This article reviews the literature since 2011 on advances in diagnosis, clinical disease manifestations, pathophysiology and treatment of Henoch-Schönlein purpura. The clinical manifestations are thought to arise from IgA depositions in blood vessel walls in the affected organs, mostly skin, gastrointestinal tract, joints and kidneys. Corticosteroids may be effective in rapid resolution of renal manifestations and treating joint and abdominal pain, but they are not proven effective for treating organ manifestations and complications, such as glomerulonephritis, bowel infarction or intussusception. Mycophenolate mofetil or cyclosporine A may be better treatment choices in case of renal involvement. Other immunosuppressive and immunomodulating drugs, such as rituximab and dapsone, are promising, but larger studies are needed to confirm these findings. Cancer screening should be considered in older males diagnosed with Henoch-Schönlein purpura. |
topic |
Henoch-Schönleinpurpura vasculitis immunoglobulinA corticosteroids |
url |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2733
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work_keys_str_mv |
AT livelinehetland henochschonleinpurpuraaliteraturereview AT kjærstisørensensusrud henochschonleinpurpuraaliteraturereview AT kimheinlindahl henochschonleinpurpuraaliteraturereview AT anettebygum henochschonleinpurpuraaliteraturereview |
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1725584624905617408 |