Systematic Understanding of the Mechanism of Baicalin against Ischemic Stroke through a Network Pharmacology Approach

Systematic Understanding of the Mechanism of Baicalin against Ischemic Stroke through a Network Pharmacology Approach

Ischemic stroke is accompanied by high mortality and morbidity rates. At present, there is no effective clinical treatment. Alternatively, traditional Chinese medicine has been widely used in China and Japan for the treatment of ischemic stroke. Baicalin is a flavonoid extracted from Scutellaria bai...

Full description

Bibliographic Details
Main Authors:	Tian Xu, Chongyang Ma, Shuning Fan, Nang Deng, Yajun Lian, Ling Tan, Weizhe Du, Shuang Zhang, Shuling Liu, Beida Ren, Zhenhan Li, Qinguo Wang, Xueqian Wang, Fafeng Cheng
Format:	Article
Language:	English
Published:	Hindawi Limited 2018-01-01
Series:	Evidence-Based Complementary and Alternative Medicine
Online Access:	http://dx.doi.org/10.1155/2018/2582843

Similar Items

Corrigendum to “Systematic Understanding of the Mechanism of Baicalin against Ischemic Stroke through a Network Pharmacology Approach”
by: Tian Xu, et al.
Published: (2019-01-01)

An Integrative Pharmacology-Based Analysis of Refined Qingkailing Injection Against Cerebral Ischemic Stroke: A Novel Combination of Baicalin, Geniposide, Cholic Acid, and Hyodeoxycholic Acid
by: Chongyang Ma, et al.
Published: (2020-05-01)

Network Pharmacology-Based Approach to Revealing Biological Mechanisms of Qingkailing Injection against IschemicStroke: Focusing on Blood-Brain Barrier
by: Shuang Zhang, et al.
Published: (2020-01-01)

Network Pharmacology and Bioinformatics Approach Reveals the Therapeutic Mechanism of Action of Baicalein in Hepatocellular Carcinoma
by: Chongyang Ma, et al.
Published: (2019-01-01)

Integrated Analysis of the Mechanisms of Da-Chai-Hu Decoction in Type 2 Diabetes Mellitus by a Network Pharmacology Approach
by: Beida Ren, et al.
Published: (2020-01-01)

A Systems Pharmacology-Based Study of the Molecular Mechanisms of San Cao Decoction for Treating Hypertension
by: Chongyang Ma, et al.
Published: (2019-01-01)

Baicalin’s Therapeutic Time Window of Neuroprotection during Transient Focal Cerebral Ischemia and Its Antioxidative Effects In Vitro and In Vivo
by: Fafeng Cheng, et al.
Published: (2013-01-01)

Erythropoietin Pathway: A Potential Target for the Treatment of Depression
by: Chongyang Ma, et al.
Published: (2016-05-01)

Baicalin Attenuates Oxygen–Glucose Deprivation/Reoxygenation–Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron–Astrocyte Cocultures
by: Changxiang Li, et al.
Published: (2021-06-01)

Synergism and rules from combination of Baicalin, Jasminoidin and Desoxycholic acid in refined Qing Kai Ling for treat ischemic stroke mice model.
by: Jian Li, et al.
Published: (2012-01-01)

Pharmacological and non-pharmacological recanalisation strategies in acute ischemic stroke
by: Anita eFrendl, et al.
Published: (2011-05-01)

Qingkailing injection ameliorates cerebral ischemia-reperfusion injury and modulates the AMPK/NLRP3 Inflammasome Signalling pathway
by: Chongyang Ma, et al.
Published: (2019-11-01)

Treatment Effects of Ischemic Stroke by Berberine, Baicalin, and Jasminoidin from Huang-Lian-Jie-Du-Decoction (HLJDD) Explored by an Integrated Metabolomics Approach
by: Qian Zhang, et al.
Published: (2017-01-01)

Systemic Revealing Pharmacological Signalling Pathway Networks in the Hippocampus of Ischaemia-Reperfusion Mice Treated with Baicalin
by: Haixia Li, et al.
Published: (2013-01-01)

Molecular mechanism of non-alcoholic fatty liver disease induced and aggravated by chronic stress through HSL/ATGL-FFA which promotes fat mobilization
by: Jie Mu, et al.
Published: (2019-10-01)

Revealing the Pharmacological Mechanism of Acorus tatarinowii in the Treatment of Ischemic Stroke Based on Network Pharmacology
by: FengZhi Liu, et al.
Published: (2020-01-01)

Study of pharmacological actions of the water extract of huangqin and its principles baicalin､wogonin and chrysin on central GAGAergic system
by: Wang, Hui-Hung, et al.
Published: (1995)

A pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke.
by: Simret Beraki, et al.
Published: (2013-01-01)

Recanalization Therapies in Acute Ischemic Stroke: Pharmacological Agents, Devices, and Combinations
by: Vijay K. Sharma, et al.
Published: (2010-01-01)

Paeoniflorin inhibits lipopolysaccharide-induced inflammation in LO2 cells by regulating RhoA/NLRP3 pathway
by: Haixia Liu, et al.
Published: (2021-04-01)

The Metabolism of Baicalin in Rat and the Biological Activities of the Metabolites
by: Yi Wang, et al.
Published: (2012-01-01)

Development of Eastern Blotting Technique for Analysis of Baicalin Using Anti-Baicalin Monoclonal Antibody
by: Osamu Morinaga, et al.
Published: (2012-11-01)

Chinese Medicine Injection Qingkailing for Treatment of Acute Ischemia Stroke: A Systematic Review of Randomized Controlled Trials
by: Fafeng Cheng, et al.
Published: (2012-01-01)

Baicalin Inhibits Ferroptosis in Intracerebral Hemorrhage
by: Lining Duan, et al.
Published: (2021-03-01)

Modulation of P1 and EGF Expression by Baicalin
by: Junwei Zhang, et al.
Published: (2012-12-01)

Network Pharmacology-Based Analysis on the Potential Biological Mechanisms of Sinisan Against Non-Alcoholic Fatty Liver Disease
by: Xiaoyi Wei, et al.
Published: (2021-08-01)

Quantitative Analysis of Baicalin in Scutellaria baicalin Georgi and Herbal Prescriptions Containing Scutellariae Radix by HPLC
by: Huei-Long Tsai, et al.
Published: (2001)

A Network Pharmacology to Explore the Mechanism of Calculus Bovis in the Treatment of Ischemic Stroke
by: Fangchen Liu, et al.
Published: (2021-01-01)

Comparing Two Different Statins in a Delayed Pharmacological Treatment for Ischemic Stroke
by: Hagerty, Kailyn M.
Published: (2012)

Anti-Depressive Effectiveness of Baicalin In Vitro and In Vivo
by: Li Liu, et al.
Published: (2019-01-01)

Ischemic and Pharmacological Preconditioning
by: V. V. Likhvantsev, et al.
Published: (2011-12-01)

Process optimization and evaluation of novel baicalin solid nanocrystals
by: Yue PF, et al.
Published: (2013-08-01)

Systems Pharmacology-Dissection of the Molecular Mechanisms of Dragon’s Blood in Improving Ischemic Stroke Prognosis
by: Meng Jiang, et al.
Published: (2020-01-01)

A Network Pharmacology Approach to Investigate the Active Compounds and Mechanisms of Musk for Ischemic Stroke
by: Changlin Zhang, et al.
Published: (2020-01-01)

Baicalin Weakens Staphylococcus aureus Pathogenicity by Targeting Sortase B
by: Guizhen Wang, et al.
Published: (2018-11-01)

Baicalin reverses radioresistance in nasopharyngeal carcinoma by downregulating autophagy
by: Cong Wang, et al.
Published: (2020-01-01)

Baicalin Protects Mice from Lethal Infection by Enterohemorrhagic Escherichia coli
by: Yong Zhang, et al.
Published: (2017-03-01)

Protective Effects of Baicalin on Experimental Myocardial Infarction in Rats
by: Longfei Wang, et al.

Nanomedicine for Ischemic Stroke
by: Xinyue Dong, et al.
Published: (2020-10-01)

Regulatory Mechanisms of Baicalin in Cardiovascular Diseases: A Review
by: Laiyun Xin, et al.
Published: (2020-11-01)

Cannot write session to /tmp/vufind_sessions/sess_ohn5ec3i3dodbmu77sl8nst8ji