Improvement of Porcine Islet Isolation by Inhibition of Trypsin Activity during Pancreas Preservation and Digestion Using α1-Antitrypsin

Improvement of Porcine Islet Isolation by Inhibition of Trypsin Activity during Pancreas Preservation and Digestion Using α1-Antitrypsin

Porcine islets are considered to be a promising resource for xenotransplantation. However, it is difficult to isolate porcine islets because of the marked fragility and rapid dissociation. Endogenous trypsin is one of the main factors to damage islets during the isolation procedure. Recent studies h...

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Bibliographic Details
Main Authors: Masayuki Shimoda, Hirofumi Noguchi, Yasutaka Fujita, Morihito Takita, Tetsuya Ikemoto, Daisuke Chujo, Bashoo Naziruddin Ph.D., Marlon F. Levy, Naoya Kobayashi, Paul A. Grayburn, Shinichi Matsumoto M.D., Ph.D.
Format: Article
Language:English
Published: SAGE Publishing 2012-03-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368911X605376

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