Evaluation of antiviral T cell responses and TSCM cells in volunteers enrolled in a phase I HIV-1 subtype C prophylactic vaccine trial in India.

Evaluation of antiviral T cell responses and TSCM cells in volunteers enrolled in a phase I HIV-1 subtype C prophylactic vaccine trial in India.

T cells play an important role in controlling viral replication during HIV infection. An effective vaccine should, therefore, lead to the induction of a strong and early viral-specific CD8+ T cell response. While polyfunctional T cell responses are thought to be important contributors to the antivir...

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Main Authors: Sivasankaran Munusamy Ponnan, Peter Hayes, Natalia Fernandez, Kannan Thiruvengadam, Sathyamurthi Pattabiram, Manohar Nesakumar, Ashokkumar Srinivasan, Sujitha Kathirvel, Janani Shankar, Rajat Goyal, Nikhil Singla, Joyeeta Mukherjee, Shweta Chatrath, Jill Gilmour, Sudha Subramanyam, Srikanth Prasad Tripathy, Soumya Swaminathan, Luke Elizabeth Hanna
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0229461

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https://doi.org/10.1371/journal.pone.0229461

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