Interference With Complex IV as a Model of Age-Related Decline in Synaptic Connectivity

Interference With Complex IV as a Model of Age-Related Decline in Synaptic Connectivity

Age-related impairment of mitochondrial function may negatively impact energy-demanding processes such as synaptic transmission thereby triggering cognitive decline and processes of neurodegeneration. Here, we present a novel model for age-related mitochondrial impairment based on partial inhibition...

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Bibliographic Details
Main Authors: Martin Kriebel, Julia Ebel, Florian Battke, Stefan Griesbach, Hansjürgen Volkmer
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cytochrome c oxidase
Cox4
mitochondria
aging
synaptic connectivity
neurodegeneration
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00043/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2020.00043/full

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