Mutational signatures of ionizing radiation in second malignancies

Ionizing radiation may induce irreparable DNA damage leading to cancer. Here, the authors identify a specific signature of mutations arising in patients exposed to ionizing radiation and suggest that radiation-induced tumorigenesis is associated with higher rates of genome-wide deletions and balance...

Full description

Bibliographic Details
Main Authors:	Sam Behjati, Gunes Gundem, David C. Wedge, Nicola D. Roberts, Patrick S. Tarpey, Susanna L. Cooke, Peter Van Loo, Ludmil B. Alexandrov, Manasa Ramakrishna, Helen Davies, Serena Nik-Zainal, Claire Hardy, Calli Latimer, Keiran M. Raine, Lucy Stebbings, Andy Menzies, David Jones, Rebecca Shepherd, Adam P. Butler, Jon W. Teague, Mette Jorgensen, Bhavisha Khatri, Nischalan Pillay, Adam Shlien, P. Andrew Futreal, Christophe Badie, ICGC Prostate Group, Ultan McDermott, G. Steven Bova, Andrea L. Richardson, Adrienne M. Flanagan, Michael R. Stratton, Peter J. Campbell
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms12605

id	doaj-6591661632a94c5d9e36a5a48f8dcf2c
record_format	Article
spelling	doaj-6591661632a94c5d9e36a5a48f8dcf2c2021-05-11T10:37:01ZengNature Publishing GroupNature Communications2041-17232016-09-01711810.1038/ncomms12605Mutational signatures of ionizing radiation in second malignanciesSam Behjati0Gunes Gundem1David C. Wedge2Nicola D. Roberts3Patrick S. Tarpey4Susanna L. Cooke5Peter Van Loo6Ludmil B. Alexandrov7Manasa Ramakrishna8Helen Davies9Serena Nik-Zainal10Claire Hardy11Calli Latimer12Keiran M. Raine13Lucy Stebbings14Andy Menzies15David Jones16Rebecca Shepherd17Adam P. Butler18Jon W. Teague19Mette Jorgensen20Bhavisha Khatri21Nischalan Pillay22Adam Shlien23P. Andrew Futreal24Christophe Badie25ICGC Prostate GroupUltan McDermott26G. Steven Bova27Andrea L. Richardson28Adrienne M. Flanagan29Michael R. Stratton30Peter J. Campbell31Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusThe Francis Crick InstituteCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusUniversity College London Cancer InstituteHistopathology, Royal National Orthopaedic Hospital NHS TrustUniversity College London Cancer InstituteCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusRadiation Effects Department, Cancer Mechanisms and Biomarkers Group, Centre for Radiation Chemical and Environmental Hazards, Public Health EnglandCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusInstitute of Biosciences and Medical Technology, BioMediTech, University of Tampere and Fimlab Laboratories, Tampere University HospitalDana-Farber Cancer InstituteUniversity College London Cancer InstituteCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome CampusIonizing radiation may induce irreparable DNA damage leading to cancer. Here, the authors identify a specific signature of mutations arising in patients exposed to ionizing radiation and suggest that radiation-induced tumorigenesis is associated with higher rates of genome-wide deletions and balanced inversions.https://doi.org/10.1038/ncomms12605
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sam Behjati Gunes Gundem David C. Wedge Nicola D. Roberts Patrick S. Tarpey Susanna L. Cooke Peter Van Loo Ludmil B. Alexandrov Manasa Ramakrishna Helen Davies Serena Nik-Zainal Claire Hardy Calli Latimer Keiran M. Raine Lucy Stebbings Andy Menzies David Jones Rebecca Shepherd Adam P. Butler Jon W. Teague Mette Jorgensen Bhavisha Khatri Nischalan Pillay Adam Shlien P. Andrew Futreal Christophe Badie ICGC Prostate Group Ultan McDermott G. Steven Bova Andrea L. Richardson Adrienne M. Flanagan Michael R. Stratton Peter J. Campbell
spellingShingle	Sam Behjati Gunes Gundem David C. Wedge Nicola D. Roberts Patrick S. Tarpey Susanna L. Cooke Peter Van Loo Ludmil B. Alexandrov Manasa Ramakrishna Helen Davies Serena Nik-Zainal Claire Hardy Calli Latimer Keiran M. Raine Lucy Stebbings Andy Menzies David Jones Rebecca Shepherd Adam P. Butler Jon W. Teague Mette Jorgensen Bhavisha Khatri Nischalan Pillay Adam Shlien P. Andrew Futreal Christophe Badie ICGC Prostate Group Ultan McDermott G. Steven Bova Andrea L. Richardson Adrienne M. Flanagan Michael R. Stratton Peter J. Campbell Mutational signatures of ionizing radiation in second malignancies Nature Communications
author_facet	Sam Behjati Gunes Gundem David C. Wedge Nicola D. Roberts Patrick S. Tarpey Susanna L. Cooke Peter Van Loo Ludmil B. Alexandrov Manasa Ramakrishna Helen Davies Serena Nik-Zainal Claire Hardy Calli Latimer Keiran M. Raine Lucy Stebbings Andy Menzies David Jones Rebecca Shepherd Adam P. Butler Jon W. Teague Mette Jorgensen Bhavisha Khatri Nischalan Pillay Adam Shlien P. Andrew Futreal Christophe Badie ICGC Prostate Group Ultan McDermott G. Steven Bova Andrea L. Richardson Adrienne M. Flanagan Michael R. Stratton Peter J. Campbell
author_sort	Sam Behjati
title	Mutational signatures of ionizing radiation in second malignancies
title_short	Mutational signatures of ionizing radiation in second malignancies
title_full	Mutational signatures of ionizing radiation in second malignancies
title_fullStr	Mutational signatures of ionizing radiation in second malignancies
title_full_unstemmed	Mutational signatures of ionizing radiation in second malignancies
title_sort	mutational signatures of ionizing radiation in second malignancies
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-09-01
description	Ionizing radiation may induce irreparable DNA damage leading to cancer. Here, the authors identify a specific signature of mutations arising in patients exposed to ionizing radiation and suggest that radiation-induced tumorigenesis is associated with higher rates of genome-wide deletions and balanced inversions.
url	https://doi.org/10.1038/ncomms12605
work_keys_str_mv	AT sambehjati mutationalsignaturesofionizingradiationinsecondmalignancies AT gunesgundem mutationalsignaturesofionizingradiationinsecondmalignancies AT davidcwedge mutationalsignaturesofionizingradiationinsecondmalignancies AT nicoladroberts mutationalsignaturesofionizingradiationinsecondmalignancies AT patrickstarpey mutationalsignaturesofionizingradiationinsecondmalignancies AT susannalcooke mutationalsignaturesofionizingradiationinsecondmalignancies AT petervanloo mutationalsignaturesofionizingradiationinsecondmalignancies AT ludmilbalexandrov mutationalsignaturesofionizingradiationinsecondmalignancies AT manasaramakrishna mutationalsignaturesofionizingradiationinsecondmalignancies AT helendavies mutationalsignaturesofionizingradiationinsecondmalignancies AT serenanikzainal mutationalsignaturesofionizingradiationinsecondmalignancies AT clairehardy mutationalsignaturesofionizingradiationinsecondmalignancies AT callilatimer mutationalsignaturesofionizingradiationinsecondmalignancies AT keiranmraine mutationalsignaturesofionizingradiationinsecondmalignancies AT lucystebbings mutationalsignaturesofionizingradiationinsecondmalignancies AT andymenzies mutationalsignaturesofionizingradiationinsecondmalignancies AT davidjones mutationalsignaturesofionizingradiationinsecondmalignancies AT rebeccashepherd mutationalsignaturesofionizingradiationinsecondmalignancies AT adampbutler mutationalsignaturesofionizingradiationinsecondmalignancies AT jonwteague mutationalsignaturesofionizingradiationinsecondmalignancies AT mettejorgensen mutationalsignaturesofionizingradiationinsecondmalignancies AT bhavishakhatri mutationalsignaturesofionizingradiationinsecondmalignancies AT nischalanpillay mutationalsignaturesofionizingradiationinsecondmalignancies AT adamshlien mutationalsignaturesofionizingradiationinsecondmalignancies AT pandrewfutreal mutationalsignaturesofionizingradiationinsecondmalignancies AT christophebadie mutationalsignaturesofionizingradiationinsecondmalignancies AT icgcprostategroup mutationalsignaturesofionizingradiationinsecondmalignancies AT ultanmcdermott mutationalsignaturesofionizingradiationinsecondmalignancies AT gstevenbova mutationalsignaturesofionizingradiationinsecondmalignancies AT andrealrichardson mutationalsignaturesofionizingradiationinsecondmalignancies AT adriennemflanagan mutationalsignaturesofionizingradiationinsecondmalignancies AT michaelrstratton mutationalsignaturesofionizingradiationinsecondmalignancies AT peterjcampbell mutationalsignaturesofionizingradiationinsecondmalignancies
_version_	1721447835876982784

Mutational signatures of ionizing radiation in second malignancies

Similar Items