Safety and Efficacy of Avaren-Fc Lectibody Targeting HCV High-Mannose Glycans in a Human Liver Chimeric Mouse ModelSummary

Safety and Efficacy of Avaren-Fc Lectibody Targeting HCV High-Mannose Glycans in a Human Liver Chimeric Mouse ModelSummary

Background & Aims: Infection with hepatitis C virus (HCV) remains a major cause of morbidity and mortality worldwide despite the recent advent of highly effective direct-acting antivirals. The envelope glycoproteins of HCV are heavily glycosylated with a high proportion of high-mannose glyca...

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Bibliographic Details
Main Authors: Matthew Dent, Krystal Hamorsky, Thibaut Vausselin, Jean Dubuisson, Yoshinari Miyata, Yoshio Morikawa, Nobuyuki Matoba
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Hepatitis C Virus
Entry Inhibitor
Plant-Made Pharmaceutical
High-Mannose Glycan
Antiviral Therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X20301338

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http://www.sciencedirect.com/science/article/pii/S2352345X20301338

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