S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization

S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization

HDL normally transports about 50–70% of plasma sphingosine 1-phosphate (S1P), and the S1P in HDL reportedly mediates several HDL-associated biological effects and signaling pathways. The HDL receptor, SR-BI, as well as the cell surface receptors for S1P (S1PRs) may be involved partially and/or compl...

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Bibliographic Details
Main Authors: Mi-Hye Lee, Kathryn M. Appleton, Hesham M. El-Shewy, Mary G. Sorci-Thomas, Michael J. Thomas, Maria F. Lopes-Virella, Louis M. Luttrell, Samar M. Hammad, Richard L. Klein
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Journal of Lipid Research
Subjects:
high density lipoprotein
sphingosine 1-phosphate
protein-fragment complementation assay
scavenger receptor BI
S1P receptors
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520314140

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http://www.sciencedirect.com/science/article/pii/S0022227520314140

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