Detection of Extended Spectrum β-lactamase Production Among Uropathogens

• Main Authors: Ritu Aggarwal, Uma Chaudhary, Rama Sikka
• Format: Article
• Language: English
• Published: Thieme Medical and Scientific Publishers Pvt. Ltd. 2009-01-01
• Series: Journal of Laboratory Physicians
• Subjects: esbl; endemicity; infection; uropathogens
• Online Access: http://www.thieme-connect.de/DOI/DOI?10.4103/0974-2727.44423

Background: Detection of extended spectrum β -lactamase (ESBL) production among uropathogens is an important marker of endemicity. Aim: Intervention of this endemic transmission is important for the control of initial outbreak of ESBL producing organisms in a hospital or specialized unit of hospital. Materials and Methods: During the study period of one and a half months, 1,551 urine samples were processed for significant bacteriuria. Two hundred gram negative bacterial isolates were tested for ESBL production. Antimicrobial sensitivity pattern was ascertained for ESBL producing isolates. Results: ESBL production was seen in 36% of isolates. All the isolates were multidrug resistant with uniform sensitivity to imipenem. Conclusion: This study reveals the significant prevalence of ESBL producing organisms in this north Indian tertiary care hospital. Constant revision of antibiotic policies with infection control interventions is suggested.