Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol.

Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol.

Flavaglines are a family of natural products from the genus Aglaia that exhibit anti-cancer activity in vitro and in vivo and inhibit translation initiation. They have been shown to modulate the activity of eIF4A, the DEAD-box RNA helicase subunit of the eukaryotic initiation factor (eIF) 4F complex...

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Main Authors: Regina Cencic, Marilyn Carrier, Gabriela Galicia-Vázquez, Marie-Eve Bordeleau, Rami Sukarieh, Annie Bourdeau, Brigitte Brem, Jose G Teodoro, Harald Greger, Michel L Tremblay, John A Porco, Jerry Pelletier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2671147?pdf=render

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http://europepmc.org/articles/PMC2671147?pdf=render

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