Hydroquinone Exposure Worsens Rheumatoid Arthritis through the Activation of the Aryl Hydrocarbon Receptor and Interleukin-17 Pathways

Hydroquinone Exposure Worsens Rheumatoid Arthritis through the Activation of the Aryl Hydrocarbon Receptor and Interleukin-17 Pathways

Rheumatoid arthritis (RA) development is strongly associated with cigarette smoke exposure, which activates the aryl hydrocarbon receptor (AhR) as a trigger for Th17 inflammatory pathways. We previously demonstrated that the exposure to hydroquinone (HQ), one of the major compounds of cigarette tar,...

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Bibliographic Details
Main Authors: Cintia Scucuglia Heluany, Paula Barbim Donate, Ayda Henriques Schneider, André Luis Fabris, Renan Augusto Gomes, Isadora Maria Villas-Boas, Denise Vilarinho Tambourgi, Tarcilia Aparecida da Silva, Gustavo Henrique Goulart Trossini, Giovanna Nalesso, Eduardo Lani Volpe Silveira, Fernando Queiroz Cunha, Sandra Helena Poliselli Farsky
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Antioxidants
Subjects:
environmental pollutant
benzene metabolite
cigarette smoking
fibroblast-like synoviocytes
antigen-induced arthritis
Online Access:https://www.mdpi.com/2076-3921/10/6/929

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https://www.mdpi.com/2076-3921/10/6/929

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