Sarcopenia is associated with hypertension in older adults: a systematic review and meta-analysis

Abstract Background Sarcopenia, particularly low handgrip strength has been observed and correlated in association with hypertension among the older people. However, the results reported in different studies were inconsistent. In the current study, we conducted a systematic review and meta-analysis...

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Main Authors: Tingting Bai, Fang Fang, Feika Li, Yan Ren, Jiaan Hu, Jiumei Cao
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Geriatrics
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12877-020-01672-y
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spelling doaj-6704cffd6a714c7286964b9b785710342020-11-25T02:31:05ZengBMCBMC Geriatrics1471-23182020-08-012011910.1186/s12877-020-01672-ySarcopenia is associated with hypertension in older adults: a systematic review and meta-analysisTingting Bai0Fang Fang1Feika Li2Yan Ren3Jiaan Hu4Jiumei Cao5Department of Geriatrics, Ruijin Hospital, Shanghai Jiaotong University School of MedicineDepartment of Geriatrics, Ruijin Hospital, Shanghai Jiaotong University School of MedicineDepartment of Geriatrics, Ruijin Hospital, Shanghai Jiaotong University School of MedicineDepartment of Geriatrics, Ruijin Hospital, Shanghai Jiaotong University School of MedicineDepartment of Geriatrics, Ruijin Hospital, Shanghai Jiaotong University School of MedicineDepartment of Geriatrics, Ruijin Hospital, Shanghai Jiaotong University School of MedicineAbstract Background Sarcopenia, particularly low handgrip strength has been observed and correlated in association with hypertension among the older people. However, the results reported in different studies were inconsistent. In the current study, we conducted a systematic review and meta-analysis to reveal the significant association between sarcopenia, handgrip strength, and hypertension in older adults. Methods PubMed, MEDLINE, Cochrane Library, and EMBASE databases were searched from inception to 15 November 2019 to retrieve the original research studies that addressed the association between sarcopenia, handgrip strength, and hypertension. All the relevant data were retrieved, analyzed, and summarized. Results Twelve articles met the inclusion criteria and a total of 21,301 participants were included in the meta-analysis. Eight eligible studies have reported the odd ratios (ORs) of hypertension and sarcopenia, and the ORs ranged from 0.41 to 4.38. When pooled the ORs together, the summarized OR was 1.29 [95% confidence interval (CI) =1.00–1.67]. The summarized OR for the Asian group 1.50 (95% CI = 1.35–1.67) was significantly higher than that of Caucasian group 1.08 (95% CI = 0.39–2.97). Eleven studies have provided the data on association between handgrip strength and hypertension. The overall OR and 95% CI was 0.99 (95% CI = 0.80–1.23), showing no significant association. Conclusion Sarcopenia was associated with hypertension, but no correlation was found between handgrip strength and hypertension in older adults.http://link.springer.com/article/10.1186/s12877-020-01672-ySarcopeniaHandgrip strengthHypertensionOlder adultsMeta-analysis
collection DOAJ
language English
format Article
sources DOAJ
author Tingting Bai
Fang Fang
Feika Li
Yan Ren
Jiaan Hu
Jiumei Cao
spellingShingle Tingting Bai
Fang Fang
Feika Li
Yan Ren
Jiaan Hu
Jiumei Cao
Sarcopenia is associated with hypertension in older adults: a systematic review and meta-analysis
BMC Geriatrics
Sarcopenia
Handgrip strength
Hypertension
Older adults
Meta-analysis
author_facet Tingting Bai
Fang Fang
Feika Li
Yan Ren
Jiaan Hu
Jiumei Cao
author_sort Tingting Bai
title Sarcopenia is associated with hypertension in older adults: a systematic review and meta-analysis
title_short Sarcopenia is associated with hypertension in older adults: a systematic review and meta-analysis
title_full Sarcopenia is associated with hypertension in older adults: a systematic review and meta-analysis
title_fullStr Sarcopenia is associated with hypertension in older adults: a systematic review and meta-analysis
title_full_unstemmed Sarcopenia is associated with hypertension in older adults: a systematic review and meta-analysis
title_sort sarcopenia is associated with hypertension in older adults: a systematic review and meta-analysis
publisher BMC
series BMC Geriatrics
issn 1471-2318
publishDate 2020-08-01
description Abstract Background Sarcopenia, particularly low handgrip strength has been observed and correlated in association with hypertension among the older people. However, the results reported in different studies were inconsistent. In the current study, we conducted a systematic review and meta-analysis to reveal the significant association between sarcopenia, handgrip strength, and hypertension in older adults. Methods PubMed, MEDLINE, Cochrane Library, and EMBASE databases were searched from inception to 15 November 2019 to retrieve the original research studies that addressed the association between sarcopenia, handgrip strength, and hypertension. All the relevant data were retrieved, analyzed, and summarized. Results Twelve articles met the inclusion criteria and a total of 21,301 participants were included in the meta-analysis. Eight eligible studies have reported the odd ratios (ORs) of hypertension and sarcopenia, and the ORs ranged from 0.41 to 4.38. When pooled the ORs together, the summarized OR was 1.29 [95% confidence interval (CI) =1.00–1.67]. The summarized OR for the Asian group 1.50 (95% CI = 1.35–1.67) was significantly higher than that of Caucasian group 1.08 (95% CI = 0.39–2.97). Eleven studies have provided the data on association between handgrip strength and hypertension. The overall OR and 95% CI was 0.99 (95% CI = 0.80–1.23), showing no significant association. Conclusion Sarcopenia was associated with hypertension, but no correlation was found between handgrip strength and hypertension in older adults.
topic Sarcopenia
Handgrip strength
Hypertension
Older adults
Meta-analysis
url http://link.springer.com/article/10.1186/s12877-020-01672-y
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