High Doses of Essential Oil of <i>Croton Zehntneri</i> Induces Renal Tubular Damage
The essential oil of <i>Croton zehntneri</i> (EOCZ) and its major compounds are known to have several biological activities. However, some evidence shows potential toxic effects of high doses of EOCZ (>300 mg/kg) in amphibian and human kidneys. The aim of the present work was to inves...
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doaj-672b1b609115400aa792e773e94b53852021-07-23T14:01:50ZengMDPI AGPlants2223-77472021-07-01101400140010.3390/plants10071400High Doses of Essential Oil of <i>Croton Zehntneri</i> Induces Renal Tubular DamageKatarine F. Silva0Diogo B. Peruchetti1Gabriela M. Sirtoli2Christina M. Takiya3Ana Acacia S. Pinheiro4José Henrique Leal-Cardoso5Celso Caruso-Neves6Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21.941-902, BrazilInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21.941-902, BrazilInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21.941-902, BrazilInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21.941-902, BrazilInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21.941-902, BrazilInstituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Ceará 60.740-000, BrazilInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21.941-902, BrazilThe essential oil of <i>Croton zehntneri</i> (EOCZ) and its major compounds are known to have several biological activities. However, some evidence shows potential toxic effects of high doses of EOCZ (>300 mg/kg) in amphibian and human kidneys. The aim of the present work was to investigate the effects on renal function of EOCZ at 300 mg/kg/day in healthy Swiss mice and a subclinical acute kidney injury (subAKI) animal model, which presents tubule-interstitial injury (TII). Four experimental groups were generated: (1) CONT group (control); (2) EOCZ, mice treated with EOCZ; (3) subAKI; (4) subAKI+EOCZ, subAKI treated simultaneously with EOCZ. EOCZ treatment induced TII measured by increases in (1) proteinuria; (2) cortical tubule-interstitial space; (3) macrophage infiltration; (4) collagen deposition. A decrease in tubular sodium reabsorption was also observed. These results were similar and nonadditive to those observed in the subAKI group. These data suggest that treatment with EOCZ at higher concentrations induces TII in mice, which could be mediated by protein overload in the proximal tubule.https://www.mdpi.com/2223-7747/10/7/1400<i>Croton zehntneri</i>essential oilproximal tubuletubulointerstitial injuryproteinuriakidney |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Katarine F. Silva Diogo B. Peruchetti Gabriela M. Sirtoli Christina M. Takiya Ana Acacia S. Pinheiro José Henrique Leal-Cardoso Celso Caruso-Neves |
spellingShingle |
Katarine F. Silva Diogo B. Peruchetti Gabriela M. Sirtoli Christina M. Takiya Ana Acacia S. Pinheiro José Henrique Leal-Cardoso Celso Caruso-Neves High Doses of Essential Oil of <i>Croton Zehntneri</i> Induces Renal Tubular Damage Plants <i>Croton zehntneri</i> essential oil proximal tubule tubulointerstitial injury proteinuria kidney |
author_facet |
Katarine F. Silva Diogo B. Peruchetti Gabriela M. Sirtoli Christina M. Takiya Ana Acacia S. Pinheiro José Henrique Leal-Cardoso Celso Caruso-Neves |
author_sort |
Katarine F. Silva |
title |
High Doses of Essential Oil of <i>Croton Zehntneri</i> Induces Renal Tubular Damage |
title_short |
High Doses of Essential Oil of <i>Croton Zehntneri</i> Induces Renal Tubular Damage |
title_full |
High Doses of Essential Oil of <i>Croton Zehntneri</i> Induces Renal Tubular Damage |
title_fullStr |
High Doses of Essential Oil of <i>Croton Zehntneri</i> Induces Renal Tubular Damage |
title_full_unstemmed |
High Doses of Essential Oil of <i>Croton Zehntneri</i> Induces Renal Tubular Damage |
title_sort |
high doses of essential oil of <i>croton zehntneri</i> induces renal tubular damage |
publisher |
MDPI AG |
series |
Plants |
issn |
2223-7747 |
publishDate |
2021-07-01 |
description |
The essential oil of <i>Croton zehntneri</i> (EOCZ) and its major compounds are known to have several biological activities. However, some evidence shows potential toxic effects of high doses of EOCZ (>300 mg/kg) in amphibian and human kidneys. The aim of the present work was to investigate the effects on renal function of EOCZ at 300 mg/kg/day in healthy Swiss mice and a subclinical acute kidney injury (subAKI) animal model, which presents tubule-interstitial injury (TII). Four experimental groups were generated: (1) CONT group (control); (2) EOCZ, mice treated with EOCZ; (3) subAKI; (4) subAKI+EOCZ, subAKI treated simultaneously with EOCZ. EOCZ treatment induced TII measured by increases in (1) proteinuria; (2) cortical tubule-interstitial space; (3) macrophage infiltration; (4) collagen deposition. A decrease in tubular sodium reabsorption was also observed. These results were similar and nonadditive to those observed in the subAKI group. These data suggest that treatment with EOCZ at higher concentrations induces TII in mice, which could be mediated by protein overload in the proximal tubule. |
topic |
<i>Croton zehntneri</i> essential oil proximal tubule tubulointerstitial injury proteinuria kidney |
url |
https://www.mdpi.com/2223-7747/10/7/1400 |
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