GSK-3 Inhibition Modulates Metalloproteases in a Model of Lung Inflammation and Fibrosis

GSK-3 Inhibition Modulates Metalloproteases in a Model of Lung Inflammation and Fibrosis

Idiopathic pulmonary fibrosis (IPF) is mainly characterized by aberrant extracellular matrix deposition, consequent to epithelial lung injury and myofibroblast activation, and inflammatory response. Glycogen synthase kinase 3 (GSK-3) is a serine–threonine kinase involved in several pathways, and its...

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Bibliographic Details
Main Authors: Francesco Cinetto, Jessica Ceccato, Ilaria Caputo, Daniela Cangiano, Barbara Montini, Francesca Lunardi, Maria Piazza, Carlo Agostini, Fiorella Calabrese, Gianpietro Semenzato, Marcello Rattazzi, Carmela Gurrieri, Riccardo Scarpa, Carla Felice, Fabrizio Vianello
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
idiopathic lung fibrosis
metalloproteases
glycogen synthase kinase 3
bleomycin-induced lung injury
extracellular matrix (ECM)
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.633054/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2021.633054/full

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