Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer.

Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer.

Triple negative breast cancer (TNBC) is a highly aggressive form of breast cancer resistant to many common treatments. In this study, we compared the effects of 12 phytochemical drugs on four cancer cell lines, and noticed that Cucurbitacin E (CuE) significantly inhibited TNBC cell growth by inducin...

Full description

Bibliographic Details
Main Authors: Yanjie Kong, Jianchao Chen, Zhongmei Zhou, Houjun Xia, Ming-Hua Qiu, Ceshi Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4114842?pdf=render
id doaj-67ef4fffe2e64e49b427c9dde9112f03
record_format Article
spelling doaj-67ef4fffe2e64e49b427c9dde9112f032020-11-25T02:45:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0197e10376010.1371/journal.pone.0103760Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer.Yanjie KongJianchao ChenZhongmei ZhouHoujun XiaMing-Hua QiuCeshi ChenTriple negative breast cancer (TNBC) is a highly aggressive form of breast cancer resistant to many common treatments. In this study, we compared the effects of 12 phytochemical drugs on four cancer cell lines, and noticed that Cucurbitacin E (CuE) significantly inhibited TNBC cell growth by inducing cell cycle G2/M phase arrest and apoptosis. CuE reduced expression of Cyclin D1, Survivin, XIAP, Bcl2, and Mcl-1 in MDA-MB-468 and SW527, and within MDA-MB-468, CuE significantly increased activation of JNK and inhibited activation of AKT and ERK. Collectively, these results suggest that CuE may be a viable compound for developing novel TNBC therapeutics.http://europepmc.org/articles/PMC4114842?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Yanjie Kong
Jianchao Chen
Zhongmei Zhou
Houjun Xia
Ming-Hua Qiu
Ceshi Chen
spellingShingle Yanjie Kong
Jianchao Chen
Zhongmei Zhou
Houjun Xia
Ming-Hua Qiu
Ceshi Chen
Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer.
PLoS ONE
author_facet Yanjie Kong
Jianchao Chen
Zhongmei Zhou
Houjun Xia
Ming-Hua Qiu
Ceshi Chen
author_sort Yanjie Kong
title Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer.
title_short Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer.
title_full Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer.
title_fullStr Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer.
title_full_unstemmed Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer.
title_sort cucurbitacin e induces cell cycle g2/m phase arrest and apoptosis in triple negative breast cancer.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2014-01-01
description Triple negative breast cancer (TNBC) is a highly aggressive form of breast cancer resistant to many common treatments. In this study, we compared the effects of 12 phytochemical drugs on four cancer cell lines, and noticed that Cucurbitacin E (CuE) significantly inhibited TNBC cell growth by inducing cell cycle G2/M phase arrest and apoptosis. CuE reduced expression of Cyclin D1, Survivin, XIAP, Bcl2, and Mcl-1 in MDA-MB-468 and SW527, and within MDA-MB-468, CuE significantly increased activation of JNK and inhibited activation of AKT and ERK. Collectively, these results suggest that CuE may be a viable compound for developing novel TNBC therapeutics.
url http://europepmc.org/articles/PMC4114842?pdf=render
work_keys_str_mv AT yanjiekong cucurbitacineinducescellcycleg2mphasearrestandapoptosisintriplenegativebreastcancer
AT jianchaochen cucurbitacineinducescellcycleg2mphasearrestandapoptosisintriplenegativebreastcancer
AT zhongmeizhou cucurbitacineinducescellcycleg2mphasearrestandapoptosisintriplenegativebreastcancer
AT houjunxia cucurbitacineinducescellcycleg2mphasearrestandapoptosisintriplenegativebreastcancer
AT minghuaqiu cucurbitacineinducescellcycleg2mphasearrestandapoptosisintriplenegativebreastcancer
AT ceshichen cucurbitacineinducescellcycleg2mphasearrestandapoptosisintriplenegativebreastcancer
_version_ 1724761308501377024

Similar Items