PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8+ T Cells

PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8+ T Cells

Phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibition by Idelalisib (CAL-101) in hematological malignancies directly induces apoptosis in cancer cells and disrupts immunological tolerance by depleting regulatory T cells. Yet, little is known about the direct impact of PI3Kδ blockade on effector T c...

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Bibliographic Details
Main Authors: Jacob S. Bowers, Kinga Majchrzak, Michelle H. Nelson, Bulent Arman Aksoy, Megan M. Wyatt, Aubrey S. Smith, Stefanie R. Bailey, Lillian R. Neal, Jeffrey E. Hammerbacher, Chrystal M. Paulos
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
adoptive cell therapy
T cell
cancer
memory
phosphatidylinositol-3-kinase
CAL-101
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01221/full

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