Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase

Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase

Abstract: Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than th...

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Bibliographic Details
Main Authors: Jun'ichi Kobayashi, Kunimi Kikuchi, Naohito Aoki, Shinya Mitsuhashi, Tadashi Okada, Hiroshi Shima, Takaaki Kubota, Yusuke Wakuda
Format: Article
Language:English
Published: MDPI AG 2006-02-01
Series:Marine Drugs
Subjects:
Protein tyrosine phosphatases
TCPTP
Inhibitors
Manzamenones
Online Access:http://www.mdpi.com/1660-3397/4/1/9/
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spelling doaj-69313788837644529adee0b4295bac9a2020-11-24T22:09:28ZengMDPI AGMarine Drugs1660-33972006-02-014191410.3390/md401009Manzamenones Inhibit T-Cell Protein Tyrosine PhosphataseJun'ichi KobayashiKunimi KikuchiNaohito AokiShinya MitsuhashiTadashi OkadaHiroshi ShimaTakaaki KubotaYusuke WakudaAbstract: Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B).http://www.mdpi.com/1660-3397/4/1/9/Protein tyrosine phosphatasesTCPTPInhibitorsManzamenones
collection DOAJ
language English
format Article
sources DOAJ
author Jun'ichi Kobayashi
Kunimi Kikuchi
Naohito Aoki
Shinya Mitsuhashi
Tadashi Okada
Hiroshi Shima
Takaaki Kubota
Yusuke Wakuda
spellingShingle Jun'ichi Kobayashi
Kunimi Kikuchi
Naohito Aoki
Shinya Mitsuhashi
Tadashi Okada
Hiroshi Shima
Takaaki Kubota
Yusuke Wakuda
Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase
Marine Drugs
Protein tyrosine phosphatases
TCPTP
Inhibitors
Manzamenones
author_facet Jun'ichi Kobayashi
Kunimi Kikuchi
Naohito Aoki
Shinya Mitsuhashi
Tadashi Okada
Hiroshi Shima
Takaaki Kubota
Yusuke Wakuda
author_sort Jun'ichi Kobayashi
title Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase
title_short Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase
title_full Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase
title_fullStr Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase
title_full_unstemmed Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase
title_sort manzamenones inhibit t-cell protein tyrosine phosphatase
publisher MDPI AG
series Marine Drugs
issn 1660-3397
publishDate 2006-02-01
description Abstract: Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B).
topic Protein tyrosine phosphatases
TCPTP
Inhibitors
Manzamenones
url http://www.mdpi.com/1660-3397/4/1/9/
work_keys_str_mv AT junichikobayashi manzamenonesinhibittcellproteintyrosinephosphatase
AT kunimikikuchi manzamenonesinhibittcellproteintyrosinephosphatase
AT naohitoaoki manzamenonesinhibittcellproteintyrosinephosphatase
AT shinyamitsuhashi manzamenonesinhibittcellproteintyrosinephosphatase
AT tadashiokada manzamenonesinhibittcellproteintyrosinephosphatase
AT hiroshishima manzamenonesinhibittcellproteintyrosinephosphatase
AT takaakikubota manzamenonesinhibittcellproteintyrosinephosphatase
AT yusukewakuda manzamenonesinhibittcellproteintyrosinephosphatase
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