Dysregulated Prefrontal Cortex Inhibition in Prepubescent and Adolescent Fragile X Mouse Model

Dysregulated Prefrontal Cortex Inhibition in Prepubescent and Adolescent Fragile X Mouse Model

Changes in excitation and inhibition are associated with the pathobiology of neurodevelopmental disorders of intellectual disability and autism and are widely described in Fragile X syndrome (FXS). In the prefrontal cortex (PFC), essential for cognitive processing, excitatory connectivity and plasti...

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Bibliographic Details
Main Authors: Ioannis Kramvis, Rhodé van Westen, Hanna C. A. Lammertse, Danai Riga, Tim S. Heistek, Alex Loebel, Sabine Spijker, Huibert D. Mansvelder, Rhiannon M. Meredith
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Fragile X
prefrontal cortex
GABA
electrophysiology
plasticity
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00088/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2020.00088/full

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