Genetic variation in CCR2 and CXCL12 genes impacts on CD4 restoration in patients initiating cART with advanced immunesupression.

Genetic variation in CCR2 and CXCL12 genes impacts on CD4 restoration in patients initiating cART with advanced immunesupression.

OBJECTIVE:We investigated the association of genetic polymorphisms in chemokine and chemokine receptor genes with poor immunological recovery in HIV patients starting combined antiretroviral therapy (cART) with low CD4 T-cell counts. METHODS:A case-control study was conducted in 412 HIV-infected pat...

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Bibliographic Details
Main Authors: Clara Restrepo, Mónica Gutierrez-Rivas, Yolanda M Pacheco, Marcial García, Julià Blanco, Luz M Medrano, María A Navarrete-Muñoz, Félix Gutiérrez, Pilar Miralles, David Dalmau, Juan Luis Gómez, Miguel Górgolas, Alfonso Cabello, Salvador Resino, José M Benito, Norma Rallón, CoRIS and the HIV Biobank integrated in the Spanish AIDS Research Network Project RIS/EPICLIN 10_2015
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0214421

Internet

https://doi.org/10.1371/journal.pone.0214421

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