The role of intestinal microbiota in development of irinotecan toxicity and in toxicity reduction through dietary fibres in rats.
CPT-11 is a drug used as chemotherapy for colorectal cancer. CPT-11 causes toxic side-effects in patients. CPT-11 toxicity has been attributed to the activity of intestinal microbiota, however, intestinal microbiota may also have protective effects in CP!-11 chemotherapy. This study aimed to elucida...
Main Authors: | Xiaoxi B Lin, Arazm Farhangfar, Rosica Valcheva, Michael B Sawyer, Levinus Dieleman, Andreas Schieber, Michael G Gänzle, Vickie Baracos |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3891650?pdf=render |
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