Characterization of Pneumococcal Colonization Dynamics and Antimicrobial Resistance Using Shotgun Metagenomic Sequencing in Intensively Sampled South African Infants

Characterization of Pneumococcal Colonization Dynamics and Antimicrobial Resistance Using Shotgun Metagenomic Sequencing in Intensively Sampled South African Infants

Background: There remains a significant proportion of deaths due to pneumococcal pneumonia in infants from low- and middle-income countries despite the marginal global declines recorded in the past decade. Monitoring changes in pneumococcal carriage is key to understanding vaccination-induced shifts...

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Bibliographic Details
Main Authors: Rendani I. Manenzhe, Felix S. Dube, Meredith Wright, Katie Lennard, Stephanie Mounaud, Stephanie W. Lo, Heather J. Zar, William C. Nierman, Mark P. Nicol, Clinton Moodley
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Public Health
Subjects:
nasopharyngeal
Streptococcus pneumoniae
pneumococcal conjugate vaccine
serotypes
shotgun metagenomic sequencing
resistance determinants
Online Access:https://www.frontiersin.org/article/10.3389/fpubh.2020.543898/full

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