The Dynamics of Hole Transfer in DNA
High-energy radiation and oxidizing agents can ionize DNA. One electron oxidation gives rise to a radical cation whose charge (hole) can migrate through DNA covering several hundreds of Å, eventually leading to irreversible oxidative damage and consequent disease. Understanding the thermody...
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doaj-6a1138045451498eb8a106f5e17b1e3e2020-11-24T22:10:06ZengMDPI AGMolecules1420-30492019-11-012422404410.3390/molecules24224044molecules24224044The Dynamics of Hole Transfer in DNAAndrea Peluso0Tonino Caruso1Alessandro Landi2Amedeo Capobianco3Dipartimento di Chimica e Biologia “A. Zambelli”, Università di Salerno, via Giovanni Paolo II, 132, I-84084 Fisciano (SA), ItalyDipartimento di Chimica e Biologia “A. Zambelli”, Università di Salerno, via Giovanni Paolo II, 132, I-84084 Fisciano (SA), ItalyDipartimento di Chimica e Biologia “A. Zambelli”, Università di Salerno, via Giovanni Paolo II, 132, I-84084 Fisciano (SA), ItalyDipartimento di Chimica e Biologia “A. Zambelli”, Università di Salerno, via Giovanni Paolo II, 132, I-84084 Fisciano (SA), ItalyHigh-energy radiation and oxidizing agents can ionize DNA. One electron oxidation gives rise to a radical cation whose charge (hole) can migrate through DNA covering several hundreds of Å, eventually leading to irreversible oxidative damage and consequent disease. Understanding the thermodynamic, kinetic and chemical aspects of the hole transport in DNA is important not only for its biological consequences, but also for assessing the properties of DNA in redox sensing or labeling. Furthermore, due to hole migration, DNA could potentially play an important role in nanoelectronics, by acting as both a template and active component. Herein, we review our work on the dynamics of hole transfer in DNA carried out in the last decade. After retrieving the thermodynamic parameters needed to address the dynamics of hole transfer by voltammetric and spectroscopic experiments and quantum chemical computations, we develop a theoretical methodology which allows for a faithful interpretation of the kinetics of the hole transport in DNA and is also capable of taking into account sequence-specific effects.https://www.mdpi.com/1420-3049/24/22/4044dna oxidationdna hole transferdnaquantum dynamicselectron transfercharge transfer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andrea Peluso Tonino Caruso Alessandro Landi Amedeo Capobianco |
spellingShingle |
Andrea Peluso Tonino Caruso Alessandro Landi Amedeo Capobianco The Dynamics of Hole Transfer in DNA Molecules dna oxidation dna hole transfer dna quantum dynamics electron transfer charge transfer |
author_facet |
Andrea Peluso Tonino Caruso Alessandro Landi Amedeo Capobianco |
author_sort |
Andrea Peluso |
title |
The Dynamics of Hole Transfer in DNA |
title_short |
The Dynamics of Hole Transfer in DNA |
title_full |
The Dynamics of Hole Transfer in DNA |
title_fullStr |
The Dynamics of Hole Transfer in DNA |
title_full_unstemmed |
The Dynamics of Hole Transfer in DNA |
title_sort |
dynamics of hole transfer in dna |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2019-11-01 |
description |
High-energy radiation and oxidizing agents can ionize DNA. One electron oxidation gives rise to a radical cation whose charge (hole) can migrate through DNA covering several hundreds of Å, eventually leading to irreversible oxidative damage and consequent disease. Understanding the thermodynamic, kinetic and chemical aspects of the hole transport in DNA is important not only for its biological consequences, but also for assessing the properties of DNA in redox sensing or labeling. Furthermore, due to hole migration, DNA could potentially play an important role in nanoelectronics, by acting as both a template and active component. Herein, we review our work on the dynamics of hole transfer in DNA carried out in the last decade. After retrieving the thermodynamic parameters needed to address the dynamics of hole transfer by voltammetric and spectroscopic experiments and quantum chemical computations, we develop a theoretical methodology which allows for a faithful interpretation of the kinetics of the hole transport in DNA and is also capable of taking into account sequence-specific effects. |
topic |
dna oxidation dna hole transfer dna quantum dynamics electron transfer charge transfer |
url |
https://www.mdpi.com/1420-3049/24/22/4044 |
work_keys_str_mv |
AT andreapeluso thedynamicsofholetransferindna AT toninocaruso thedynamicsofholetransferindna AT alessandrolandi thedynamicsofholetransferindna AT amedeocapobianco thedynamicsofholetransferindna AT andreapeluso dynamicsofholetransferindna AT toninocaruso dynamicsofholetransferindna AT alessandrolandi dynamicsofholetransferindna AT amedeocapobianco dynamicsofholetransferindna |
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