Discovery and Validation of a Three-Cytokine Plasma Signature as a Biomarker for Diagnosis of Pediatric Tuberculosis
Pediatric TB poses challenge in diagnosis due to the paucibacillary nature of the disease. We conducted a prospective diagnostic study to identify immune biomarkers of pediatric TB and controls (discovery cohort) and obtained a separate “validation” cohort of confirmed cases of pediatric TB and cont...
Main Authors: | Nathella Pavan Kumar, Syed Hissar, Kannan Thiruvengadam, Velayuthum V. Banurekha, N. Suresh, Janani Shankar, Elilarasi S, Gomathi N S, Kalpana S, Ganesh J, Aravind M A, Dhanaraj Baskaran, Srikanth Tripathy, Soumya Swaminathan, Subash Babu |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-04-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.653898/full |
Similar Items
-
Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases Are Potential Biomarkers of Pulmonary and Extra-Pulmonary Tuberculosis
by: Gokul Raj Kathamuthu, et al.
Published: (2020-03-01) -
Effect of anti-tuberculosis treatment on the systemic levels of tissue inhibitors of metalloproteinases in tuberculosis – Diabetes co-morbidity
by: Nathella Pavan Kumar, et al.
Published: (2021-05-01) -
Systemic RAGE ligands are upregulated in tuberculosis individuals with diabetes co-morbidity and modulated by anti-tuberculosis treatment and metformin therapy
by: Nathella Pavan Kumar, et al.
Published: (2019-12-01) -
Plasma Eicosanoid Levels in Tuberculosis and Tuberculosis-Diabetes Co-morbidity Are Associated With Lung Pathology and Bacterial Burden
by: Nathella Pavan Kumar, et al.
Published: (2019-10-01) -
The recent trend in mycobacterial strain diversity among extra pulmonary lymph node tuberculosis and their association with drug resistance and the host immunological response in South India
by: Shanmugam Sivakumar, et al.
Published: (2020-11-01)