Targeting Bacterial Gyrase with Cystobactamid, Fluoroquinolone, and Aminocoumarin Antibiotics Induces Distinct Molecular Signatures in <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>

Targeting Bacterial Gyrase with Cystobactamid, Fluoroquinolone, and Aminocoumarin Antibiotics Induces Distinct Molecular Signatures in <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>

ABSTRACT The design of novel antibiotics relies on a profound understanding of their mechanism of action. While it has been shown that cellular effects of antibiotics cluster according to their molecular targets, we investigated whether compounds binding to different sites of the same target can be...

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Bibliographic Details
Main Authors: Raimo Franke, Heike Overwin, Susanne Häussler, Mark Brönstrup
Format: Article
Language:English
Published: American Society for Microbiology 2021-08-01
Series:mSystems
Subjects:
antibiotics
Pseudomonas aeruginosa
mode of action
gyrase
metabolomics
RNA sequencing
Online Access:https://journals.asm.org/doi/10.1128/mSystems.00610-21

Internet

https://journals.asm.org/doi/10.1128/mSystems.00610-21

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