The anti-cancer drugs curaxins target spatial genome organization
Curaxins are a recently discovered class of anti-cancer agents that disturbs DNA/histone interactions within. Here the authors provide evidence that curaxins affect the spatial genome organization and compromise enhancer-promoter communication necessary for expression of several oncogenes, including...
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Bibliographic Details
Main Authors: |
Omar L. Kantidze,
Artem V. Luzhin,
Ekaterina V. Nizovtseva,
Alfiya Safina,
Maria E. Valieva,
Arkadiy K. Golov,
Artem K. Velichko,
Alexander V. Lyubitelev,
Alexey V. Feofanov,
Katerina V. Gurova,
Vasily M. Studitsky,
Sergey V. Razin |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2019-03-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-019-09500-7
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