Dietary Flavonoids in the Prevention of T2D: An Overview
Type 2 diabetes (T2D) is a progressive metabolic disease that is increasing in prevalence globally. It is well established that insulin resistance (IR) and a progressive decline in functional β-cell mass are hallmarks of developing T2D. Obesity is a leading pathogenic factor for developing IR. Const...
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doaj-6aef3a2d340c4b53b14b9627a5ac32a02020-11-25T02:32:25ZengMDPI AGNutrients2072-66432018-03-0110443810.3390/nu10040438nu10040438Dietary Flavonoids in the Prevention of T2D: An OverviewHana Alkhalidy0Yao Wang1Dongmin Liu2Department of Human Nutrition, Foods and Exercise, College of Agricultural and Life Sciences, Virginia Tech, Blacksburg, VA 24060, USADepartment of Human Nutrition, Foods and Exercise, College of Agricultural and Life Sciences, Virginia Tech, Blacksburg, VA 24060, USADepartment of Human Nutrition, Foods and Exercise, College of Agricultural and Life Sciences, Virginia Tech, Blacksburg, VA 24060, USAType 2 diabetes (T2D) is a progressive metabolic disease that is increasing in prevalence globally. It is well established that insulin resistance (IR) and a progressive decline in functional β-cell mass are hallmarks of developing T2D. Obesity is a leading pathogenic factor for developing IR. Constant IR will progress to T2D when β-cells are unable to secret adequate amounts of insulin to compensate for decreased insulin sensitivity. Recently, a considerable amount of research has been devoted to identifying naturally occurring anti-diabetic compounds that are abundant in certain types of foods. Flavonoids are a group of polyphenols that have drawn great interest for their various health benefits. Results from many clinical and animal studies demonstrate that dietary intake of flavonoids might be helpful in preventing T2D, although cellular and molecular mechanisms underlying these effects are still not completely understood. This review discusses our current understanding of the pathophysiology of T2D and highlights the potential anti-diabetic effects of flavonoids and mechanisms of their actions.http://www.mdpi.com/2072-6643/10/4/438flavonoidstype 2 diabetesinsulin resistance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hana Alkhalidy Yao Wang Dongmin Liu |
spellingShingle |
Hana Alkhalidy Yao Wang Dongmin Liu Dietary Flavonoids in the Prevention of T2D: An Overview Nutrients flavonoids type 2 diabetes insulin resistance |
author_facet |
Hana Alkhalidy Yao Wang Dongmin Liu |
author_sort |
Hana Alkhalidy |
title |
Dietary Flavonoids in the Prevention of T2D: An Overview |
title_short |
Dietary Flavonoids in the Prevention of T2D: An Overview |
title_full |
Dietary Flavonoids in the Prevention of T2D: An Overview |
title_fullStr |
Dietary Flavonoids in the Prevention of T2D: An Overview |
title_full_unstemmed |
Dietary Flavonoids in the Prevention of T2D: An Overview |
title_sort |
dietary flavonoids in the prevention of t2d: an overview |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2018-03-01 |
description |
Type 2 diabetes (T2D) is a progressive metabolic disease that is increasing in prevalence globally. It is well established that insulin resistance (IR) and a progressive decline in functional β-cell mass are hallmarks of developing T2D. Obesity is a leading pathogenic factor for developing IR. Constant IR will progress to T2D when β-cells are unable to secret adequate amounts of insulin to compensate for decreased insulin sensitivity. Recently, a considerable amount of research has been devoted to identifying naturally occurring anti-diabetic compounds that are abundant in certain types of foods. Flavonoids are a group of polyphenols that have drawn great interest for their various health benefits. Results from many clinical and animal studies demonstrate that dietary intake of flavonoids might be helpful in preventing T2D, although cellular and molecular mechanisms underlying these effects are still not completely understood. This review discusses our current understanding of the pathophysiology of T2D and highlights the potential anti-diabetic effects of flavonoids and mechanisms of their actions. |
topic |
flavonoids type 2 diabetes insulin resistance |
url |
http://www.mdpi.com/2072-6643/10/4/438 |
work_keys_str_mv |
AT hanaalkhalidy dietaryflavonoidsinthepreventionoft2danoverview AT yaowang dietaryflavonoidsinthepreventionoft2danoverview AT dongminliu dietaryflavonoidsinthepreventionoft2danoverview |
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