Syndecan-1 Promotes Angiogenesis in Triple-Negative Breast Cancer through the Prognostically Relevant Tissue Factor Pathway and Additional Angiogenic Routes

Syndecan-1 Promotes Angiogenesis in Triple-Negative Breast Cancer through the Prognostically Relevant Tissue Factor Pathway and Additional Angiogenic Routes

Triple-negative breast cancer (TNBC) is characterized by increased angiogenesis, metastasis, and poor survival. Dysregulation of the cell surface heparan sulfate proteoglycan and signaling co-receptor Syndecan-1 is linked to poor prognosis. To study its role in angiogenesis, we silenced Syndecan-1 i...

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Bibliographic Details
Main Authors: Eyyad Nassar, Nourhan Hassan, Eslam A. El-Ghonaimy, Hebatallah Hassan, Mahmoud Salah Abdullah, Theresa V. Rottke, Ludwig Kiesel, Burkhard Greve, Sherif Abdelaziz Ibrahim, Martin Götte
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
triple-negative breast cancer
prognosis
Syndecan-1
CD138
angiogenesis
tissue factor
Online Access:https://www.mdpi.com/2072-6694/13/10/2318

Internet

https://www.mdpi.com/2072-6694/13/10/2318

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