Block of the Mevalonate Pathway Triggers Oxidative and Inflammatory Molecular Mechanisms Modulated by Exogenous Isoprenoid Compounds

Block of the Mevalonate Pathway Triggers Oxidative and Inflammatory Molecular Mechanisms Modulated by Exogenous Isoprenoid Compounds

Deregulation of the mevalonate pathway is known to be involved in a number of diseases that exhibit a systemic inflammatory phenotype and often neurological involvements, as seen in patients suffering from a rare disease called mevalonate kinase deficiency (MKD). One of the molecular mechanisms unde...

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Bibliographic Details
Main Authors: Paola Maura Tricarico, Giulio Kleiner, Erica Valencic, Giuseppina Campisciano, Martina Girardelli, Sergio Crovella, Alessandra Knowles, Annalisa Marcuzzi
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:International Journal of Molecular Sciences
Subjects:
isoprenoids
mevalonate
inflammation
phytol
lycopene
Online Access:http://www.mdpi.com/1422-0067/15/4/6843

Internet

http://www.mdpi.com/1422-0067/15/4/6843

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