Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF

Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF

Myelosuppressive injuries lead to chronic MAPK activation and impair blood reconstitution. Here, the authors show that chronic activation endothelial MAPK impairs hematopoietic stem cell (HSC) function through NFkB signaling, and that post-myelosuppressive HSC defects can be reversed by administrati...

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Bibliographic Details
Main Authors: Pradeep Ramalingam, Michael G. Poulos, Elisa Lazzari, Michael C. Gutkin, David Lopez, Christopher C. Kloss, Michael J. Crowley, Lizabeth Katsnelson, Ana G. Freire, Matthew B. Greenblatt, Christopher Y. Park, Jason M. Butler
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14478-8

Internet

https://doi.org/10.1038/s41467-020-14478-8

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