Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF
Myelosuppressive injuries lead to chronic MAPK activation and impair blood reconstitution. Here, the authors show that chronic activation endothelial MAPK impairs hematopoietic stem cell (HSC) function through NFkB signaling, and that post-myelosuppressive HSC defects can be reversed by administrati...
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Bibliographic Details
| Main Authors: |
Pradeep Ramalingam,
Michael G. Poulos,
Elisa Lazzari,
Michael C. Gutkin,
David Lopez,
Christopher C. Kloss,
Michael J. Crowley,
Lizabeth Katsnelson,
Ana G. Freire,
Matthew B. Greenblatt,
Christopher Y. Park,
Jason M. Butler |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-14478-8
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