Methicillin resistance & inducible clindamycin resistance in Staphylococcus aureus
Background & objectives: Methicillin resistant Staphylococcus aureus (MRSA) isolates with inducible clindamycin resistance (iCR) are resistant to erythromycin and sensitive to clindamycin on routine testing and inducible clindamycin resistance can only be identified by D-test. This study was aim...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2016-01-01
|
Series: | Indian Journal of Medical Research |
Subjects: | |
Online Access: | http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2016;volume=143;issue=3;spage=362;epage=364;aulast=Ghosh |
id |
doaj-6b5b064e452f436da98a435d27ad2996 |
---|---|
record_format |
Article |
spelling |
doaj-6b5b064e452f436da98a435d27ad29962020-11-24T23:40:12ZengWolters Kluwer Medknow PublicationsIndian Journal of Medical Research0971-59162016-01-01143336236410.4103/0971-5916.182628Methicillin resistance & inducible clindamycin resistance in Staphylococcus aureusSoumyadeep GhoshMandira BanerjeeBackground & objectives: Methicillin resistant Staphylococcus aureus (MRSA) isolates with inducible clindamycin resistance (iCR) are resistant to erythromycin and sensitive to clindamycin on routine testing and inducible clindamycin resistance can only be identified by D-test. This study was aimed to detect methicillin resistance and iCR among S. aureus isolates, effectiveness of some commonly used antibiotics and correlation between methicillin resistance and iCR. Methods: The present cross-sectional study included 46 S. aureus isolates subjected to Kirby-Bauer's disk diffusion method for antibiotic susceptibility testing (AST) to estimate MRSA and resistance to some commonly used antibiotics. D-test was employed to detect iCR. Results: Eleven of the 46 (23.9%) isolates tested were MRSA. Overall, 19 (41.3%) isolates showed of iCR. Vancomycin and linezolid were found to be 100 per cent effective. A positive Karl-Pearson's coefficient of correlation (0.89) between methicillin resistance and iCR was obtained. Interpretation & conclusions: Detection of iCR is important for the use of clindamycin in MRSA infections. Methicillin resistance and iCR appear to be clinically unrelated.http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2016;volume=143;issue=3;spage=362;epage=364;aulast=GhoshD-test - inducible clindamycin-resistance - methicillin-resistance - MRSA |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Soumyadeep Ghosh Mandira Banerjee |
spellingShingle |
Soumyadeep Ghosh Mandira Banerjee Methicillin resistance & inducible clindamycin resistance in Staphylococcus aureus Indian Journal of Medical Research D-test - inducible clindamycin-resistance - methicillin-resistance - MRSA |
author_facet |
Soumyadeep Ghosh Mandira Banerjee |
author_sort |
Soumyadeep Ghosh |
title |
Methicillin resistance & inducible clindamycin resistance in Staphylococcus aureus |
title_short |
Methicillin resistance & inducible clindamycin resistance in Staphylococcus aureus |
title_full |
Methicillin resistance & inducible clindamycin resistance in Staphylococcus aureus |
title_fullStr |
Methicillin resistance & inducible clindamycin resistance in Staphylococcus aureus |
title_full_unstemmed |
Methicillin resistance & inducible clindamycin resistance in Staphylococcus aureus |
title_sort |
methicillin resistance & inducible clindamycin resistance in staphylococcus aureus |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Medical Research |
issn |
0971-5916 |
publishDate |
2016-01-01 |
description |
Background & objectives: Methicillin resistant Staphylococcus aureus (MRSA) isolates with inducible clindamycin resistance (iCR) are resistant to erythromycin and sensitive to clindamycin on routine testing and inducible clindamycin resistance can only be identified by D-test. This study was aimed to detect methicillin resistance and iCR among S. aureus isolates, effectiveness of some commonly used antibiotics and correlation between methicillin resistance and iCR.
Methods: The present cross-sectional study included 46 S. aureus isolates subjected to Kirby-Bauer's disk diffusion method for antibiotic susceptibility testing (AST) to estimate MRSA and resistance to some commonly used antibiotics. D-test was employed to detect iCR.
Results: Eleven of the 46 (23.9%) isolates tested were MRSA. Overall, 19 (41.3%) isolates showed of iCR. Vancomycin and linezolid were found to be 100 per cent effective. A positive Karl-Pearson's coefficient of correlation (0.89) between methicillin resistance and iCR was obtained.
Interpretation & conclusions: Detection of iCR is important for the use of clindamycin in MRSA infections. Methicillin resistance and iCR appear to be clinically unrelated. |
topic |
D-test - inducible clindamycin-resistance - methicillin-resistance - MRSA |
url |
http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2016;volume=143;issue=3;spage=362;epage=364;aulast=Ghosh |
work_keys_str_mv |
AT soumyadeepghosh methicillinresistanceinducibleclindamycinresistanceinstaphylococcusaureus AT mandirabanerjee methicillinresistanceinducibleclindamycinresistanceinstaphylococcusaureus |
_version_ |
1725510637963968512 |