Dynamics of glycoprotein charge in the evolutionary history of human influenza.

Influenza viruses show a significant capacity to evade host immunity; this is manifest both as large occasional jumps in the antigenic phenotype of viral surface molecules and in gradual antigenic changes leading to annual influenza epidemics in humans. Recent mouse studies show that avidity for hos...

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Bibliographic Details
Main Authors: Nimalan Arinaminpathy, Bryan Grenfell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3012697?pdf=render